| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 05/14 00:00 | 142 | [2] ARL Renegades v DC Defenders [1] | L | 35-26 |
| 04/30 19:00 | 2 | [2] SEA Sea Dragons v DC Defenders [1] | W | 21-37 |
| 04/22 19:00 | - | [1] DC Defenders v SA Brahmas [3] | W | 29-28 |
| 04/16 16:00 | - | [2] ARL Renegades v DC Defenders [1] | W | 26-28 |
| 04/09 23:00 | - | [1] DC Defenders v SEA Sea Dragons [3] | W | 34-33 |
| 04/01 22:00 | - | [1] DC Defenders v ORL Guardians [4] | L | 36-37 |
| 03/27 23:00 | - | HOU Roughnecks v DC Defenders | W | 26-37 |
| 03/18 23:00 | - | [1] DC Defenders v STL BattleHawks [2] | W | 28-20 |
| 03/12 23:00 | - | [4] VGS Vipers v DC Defenders [1] | W | 18-32 |
| 03/05 18:00 | - | [2] STL BattleHawks v DC Defenders [1] | W | 28-34 |
| 02/26 00:00 | - | [2] DC Defenders v VGS Vipers [3] | W | 18-6 |
| 02/20 01:00 | - | [2] SEA Sea Dragons v DC Defenders [2] | W | 18-22 |
| 03/15 20:00 | - | DAL Renegades v DC Defenders | - | Postponed |
| 03/08 19:00 | - | STL BattleHawks v DC Defenders | W | 6-15 |
| 03/02 00:00 | - | DC Defenders v TB Vipers | L | 0-25 |
| 02/23 23:00 | - | DC Defenders v LA Wildcats | L | 9-39 |
| 02/15 19:00 | - | NY Guardians v DC Defenders | W | 0-27 |
| 02/08 19:00 | - | SEA Dragons v DC Defenders | W | 19-31 |