| Date | R | Home v Away | - | |
|---|---|---|---|---|
| 04/22 16:00 | - | [4] ORL Guardians v STL BattleHawks [2] | L | 28-53 |
| 04/15 23:00 | - | [4] ORL Guardians v SA Brahmas [3] | L | 23-25 |
| 04/08 20:00 | - | [2] ARL Renegades v ORL Guardians [4] | L | 18-16 |
| 04/01 22:00 | - | [1] DC Defenders v ORL Guardians [4] | W | 36-37 |
| 03/25 17:00 | - | [3] SEA Sea Dragons v ORL Guardians [4] | L | 26-19 |
| 03/19 02:00 | - | [4] ORL Guardians v VGS Vipers [4] | L | 32-35 |
| 03/12 00:00 | - | [1] HOU Roughnecks v ORL Guardians [4] | L | 44-16 |
| 03/05 21:00 | - | [4] ORL Guardians v ARL Renegades [2] | L | 9-10 |
| 02/26 21:00 | - | [4] SA Brahmas v ORL Guardians [3] | L | 30-12 |
| 02/19 01:30 | - | [2] ORL Guardians v HOU Roughnecks [2] | L | 12-33 |
| 03/14 18:00 | - | HOU Roughnecks v NY Guardians | - | Postponed |
| 03/07 22:00 | - | NY Guardians v DAL Renegades | W | 30-12 |
| 02/29 19:00 | - | LA Wildcats v NY Guardians | W | 14-17 |
| 02/23 20:00 | - | NY Guardians v STL BattleHawks | L | 9-29 |
| 02/15 19:00 | - | NY Guardians v DC Defenders | L | 0-27 |
| 02/09 19:00 | - | TB Vipers v NY Guardians | W | 3-23 |