Head to Head
| Mexico U20 League | 2022/07/08 14:00 | Puebla U20 v Santos Laguna U20 | D | 2-2 |
| Mexico U20 League | 2022/03/18 15:00 | Puebla U20 v Santos Laguna U20 | W | 0-1 |
| Mexico U20 League | 2021/09/19 16:00 | Santos Laguna U20 v Puebla U20 | W | 4-2 |
| Mexico U20 League | 2021/05/02 16:00 | Santos Laguna U20 v Puebla U20 | L | 2-3 |
| Mexico U20 League | 2020/10/02 14:00 | Puebla U20 v Santos Laguna U20 | L | 2-1 |
| Mexico U20 League | 2020/02/07 18:00 | Puebla U20 v Santos Laguna U20 | W | 1-3 |
| Mexico U20 League | 2019/08/11 16:00 | Santos Laguna U20 v Puebla U20 | W | 5-2 |
| Mexico U20 League | 2019/01/18 18:00 | Puebla U20 v Santos Laguna U20 | D | 1-1 |
Home History
| Mexico U20 League | 2023/02/18 15:00 | Atletico San Luis U20 v Santos Laguna U20 | W | 0-1 |
| Mexico U20 League | 2023/02/10 16:00 | FC Juarez U20 v Santos Laguna U20 | L | 1-0 |
| Mexico U20 League | 2023/02/04 17:00 | Santos Laguna U20 v Club America U20 | L | 0-1 |
| Mexico U20 League | 2023/01/26 15:00 | Atlas U20 v Santos Laguna U20 | W | 1-2 |
| Mexico U20 League | 2023/01/20 16:00 | Mazatlan FC U20 v Santos Laguna U20 | W | 2-3 |
| Mexico U20 League | 2023/01/14 17:00 | Santos Laguna U20 v Unam Pumas U20 | L | 1-6 |
| Mexico U20 League | 2023/01/08 17:00 | Santos Laguna U20 v Tigres U20 | L | 0-1 |
| Mexico U20 League | 2022/10/09 17:00 | Pachuca U20 v Santos Laguna U20 | L | 1-0 |
Away History
| Mexico U20 League | 2023/02/17 15:00 | Puebla U20 v Cruz Azul U20 | D | 2-2 |
| Mexico U20 League | 2023/02/14 15:00 | Leon U20 v Puebla U20 | W | 2-4 |
| Mexico U20 League | 2023/02/10 15:00 | Puebla U20 v Mazatlan FC U20 | W | 4-0 |
| Mexico U20 League | 2023/02/02 15:00 | Atletico San Luis U20 v Puebla U20 | L | 3-1 |
| Mexico U20 League | 2023/01/27 15:00 | Puebla U20 v Monterrey U20 | W | 2-1 |
| Mexico U20 League | 2023/01/21 15:00 | Club America U20 v Puebla U20 | L | 2-1 |
| Mexico U20 League | 2023/01/13 15:00 | Puebla U20 v Queretaro U20 | L | 1-2 |
| Mexico U20 League | 2023/01/09 17:00 | Pachuca U20 v Puebla U20 | W | 3-4 |