[9] Club America 1-0 Santos Laguna [12] 2019-04-28 00:00
Stadium: Estadio Azteca Round: 16
Referee: Jorge Isaac Rojas Castillo Home Manager: Miguel Herrera Away Manager: Guillermo Almada
Head to Head
| World Club Friendlies | 2018/12/29 22:30 | Club America v Santos Laguna | D | 1-1 |
| Mexico Liga MX | 2018/11/12 00:00 | Santos Laguna v Club America | D | 1-1 |
| Mexico Liga MX | 2018/05/14 00:00 | Club America v Santos Laguna | D | 2-2 |
| Mexico Liga MX | 2018/05/11 00:30 | Santos Laguna v Club America | L | 4-1 |
| Mexico Liga MX | 2018/04/29 02:00 | Club America v Santos Laguna | W | 1-0 |
| Mexico Liga MX | 2017/11/20 00:30 | Santos Laguna v Club America | W | 0-1 |
| Europe Friendlies | 2017/07/06 01:30 | Club America v Santos Laguna | W | 3-2 |
| Mexico Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | L | 2-1 |
Home History
| Mexico Liga MX | 2019/04/21 17:00 | Toluca v Club America | L | 3-2 |
| Mexico Liga MX | 2019/04/14 23:00 | Club America v Cruz Azul | D | 0-0 |
| Mexico Cup | 2019/04/11 02:00 | Juarez FC v Club America | W | 0-1 |
| Mexico Liga MX | 2019/04/07 03:06 | Tijuana v Club America | L | 3-2 |
| Mexico Cup | 2019/04/03 02:15 | Club America v Tijuana | W | 4-0 |
| Mexico Liga MX | 2019/03/31 01:00 | Club America v Tigres UANL | W | 3-0 |
| World Club Friendlies | 2019/03/24 01:30 | Club America v Atlas | D | 2-2 |
| Mexico Liga MX | 2019/03/17 01:00 | Chivas Guadalajara v Club America | W | 0-2 |
Away History
| Mexico Liga MX | 2019/04/21 23:06 | Santos Laguna v Queretaro | W | 2-1 |
| Mexico Liga MX | 2019/04/15 01:30 | Monterrey v Santos Laguna | L | 4-0 |
| CONCACAF Champions Cup | 2019/04/11 00:00 | Santos Laguna v Tigres UANL | W | 3-2 |
| Mexico Liga MX | 2019/04/07 23:06 | Santos Laguna v Pachuca | D | 0-0 |
| CONCACAF Champions Cup | 2019/04/04 02:00 | Tigres UANL v Santos Laguna | L | 3-0 |
| Mexico Liga MX | 2019/03/30 03:00 | Atlas v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2019/03/18 00:06 | Santos Laguna v Necaxa | L | 1-2 |
| CONCACAF Champions Cup | 2019/03/13 01:00 | Santos Laguna v New York Red Bulls | W | 4-2 |