[55] Louisville 24-35 Florida State [100] 2019-09-21 19:30
Stadium: Bobby Bowden Field at Doak Campbell Stadium Round: 1
Home Manager: Willie Taggart Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2018/09/29 19:30 | Florida State v Louisville | L | 28-24 |
| NCAAF | 2017/10/21 16:00 | Florida State v Louisville | W | 28-31 |
| NCAAF | 2017/10/21 16:00 | Louisville v Florida State | W | 31-28 |
| NCAAF | 2016/09/17 16:00 | Florida State v Louisville | W | 20-63 |
| NCAAF | 2015/10/17 16:00 | Florida State v Louisville | L | 41-21 |
| NCAAF | 2014/10/30 23:30 | Louisville v Florida State | L | 31-42 |
| NCAAF | 2002/09/26 12:00 | Louisville v Florida State | W | 26-20 |
| NCAAF | 2000/09/23 12:00 | Florida State v Louisville | L | 31-0 |
Home History
| NCAAF | 2019/09/14 20:00 | Western Kentucky v Louisville | W | 21-38 |
| NCAAF | 2019/09/07 23:00 | Eastern Kentucky v Louisville | W | 0-42 |
| NCAAF | 2019/09/03 00:00 | Notre Dame v Louisville | L | 35-17 |
| NCAAF | 2018/11/25 00:00 | Kentucky v Louisville | L | 56-10 |
| NCAAF | 2018/11/17 17:20 | NC State v Louisville | L | 52-10 |
| NCAAF | 2018/11/10 00:00 | Louisville v Syracuse | L | 23-54 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | L | 16-77 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | L | 56-35 |
Away History
| NCAAF | 2019/09/14 23:30 | Florida State v Virginia | L | 24-31 |
| NCAAF | 2019/09/07 21:00 | UL Monroe v Florida State | W | 44-45 |
| NCAAF | 2019/08/31 16:00 | Boise State v Florida State | L | 36-31 |
| NCAAF | 2018/11/24 17:00 | Florida v Florida State | L | 41-14 |
| NCAAF | 2018/11/17 20:30 | Boston College v Florida State | W | 21-22 |
| NCAAF | 2018/11/11 00:30 | Florida State v Notre Dame | L | 13-42 |
| NCAAF | 2018/11/03 19:30 | Florida State v NC State | L | 28-47 |
| NCAAF | 2018/10/27 16:00 | Clemson v Florida State | L | 59-10 |