[2] Velez Sarsfield 1-0 Barcelona Guayaquil [1] 2021-07-14 22:15
Stadium: Jose Amalfitani Round: 4
Referee: Raphael Claus Home Manager: Mauricio Pellegrino Away Manager: Fabian Bustos
Home History
| Copa Libertadores | 2021/05/28 00:00 | Flamengo v Velez Sarsfield | D | 0-0 |
| Copa Libertadores | 2021/05/19 22:00 | Velez Sarsfield v Union La Calera | W | 2-1 |
| Argentina Copa de la Liga Profesional | 2021/05/16 15:00 | Velez Sarsfield v Racing Club | L | 2-4 |
| Copa Libertadores | 2021/05/13 22:00 | Velez Sarsfield v LDU Quito | W | 3-1 |
| Argentina Copa de la Liga Profesional | 2021/05/08 18:30 | Gimnasia LP v Velez Sarsfield | W | 0-5 |
| Copa Libertadores | 2021/05/04 22:15 | Union La Calera v Velez Sarsfield | W | 0-2 |
| Argentina Copa de la Liga Profesional | 2021/04/30 21:00 | Velez Sarsfield v Patronato Parana | W | 1-0 |
| Copa Libertadores | 2021/04/27 22:15 | LDU Quito v Velez Sarsfield | L | 3-1 |
Away History
| Ecuador LigaPro Serie A | 2021/07/10 22:00 | Barcelona Guayaquil v Emelec | D | 1-1 |
| Ecuador Super Cup | 2021/06/26 20:00 | Barcelona Guayaquil v LDU Quito | L | 0-1 |
| Ecuador Super Cup | 2021/06/23 01:00 | Barcelona Guayaquil v Club 9 de Octubre | W | 1-0 |
| Ecuador LigaPro Serie A | 2021/05/31 00:00 | Universidad Catolica del Ecuador v Barcelona Guayaquil | L | 2-0 |
| Copa Libertadores | 2021/05/27 00:00 | Barcelona Guayaquil v Santos | W | 3-1 |
| Ecuador LigaPro Serie A | 2021/05/24 00:00 | Barcelona Guayaquil v Olmedo | W | 4-0 |
| Copa Libertadores | 2021/05/21 00:00 | Boca Juniors v Barcelona Guayaquil | D | 0-0 |
| Ecuador LigaPro Serie A | 2021/05/17 00:00 | Club 9 de Octubre v Barcelona Guayaquil | W | 0-1 |