Stadium: Cowboy Stadium Round: 1
Home Manager: Frank Wilson Away Manager: Tim Rebowe
| NCAAF | 2021/04/03 17:00 | Nicholls State v McNeese State | L | 31-43 |
| NCAAF | 2019/11/16 21:00 | McNeese State v Nicholls State | W | 20-34 |
| NCAAF | 2018/09/15 23:00 | Nicholls State v McNeese State | L | 10-20 |
| NCAAF | 2017/09/01 00:00 | Nicholls State v McNeese State | W | 37-35 |
| NCAAF | 2021/10/30 17:00 | Northwestern State v Nicholls State | W | 21-42 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | W | 44-14 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | L | 21-38 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | L | 58-48 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | W | 17-48 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | W | 14-31 |
| NCAAF | 2021/09/11 23:00 | Nicholls State v Lafayette | L | 24-27 |
| NCAAF | 2021/09/04 23:00 | Nicholls State v Memphis | L | 17-42 |
| NCAAF | 2021/10/30 23:00 | McNeese State v SE Louisiana | L | 20-23 |
| NCAAF | 2021/10/23 17:00 | Incarnate Word v McNeese State | W | 20-28 |
| NCAAF | 2021/10/16 20:00 | McNeese State v Northwestern State | W | 35-17 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana v McNeese State | L | 38-35 |
| NCAAF | 2021/09/25 16:00 | McNeese State v Incarnate Word | L | 0-31 |
| NCAAF | 2021/09/18 23:00 | McNeese State v Southern | W | 31-24 |
| NCAAF | 2021/09/12 00:00 | McNeese State v LSU | L | 7-34 |
| NCAAF | 2021/09/04 17:00 | McNeese State v West Florida | L | 36-42 |