Stadium: Husky Stadium Round: 1
Home Manager: Vic Shealy Away Manager: Tim Rebowe
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | W | 17-48 |
| NCAAF | 2019/11/09 21:00 | Houston Christian v Nicholls State | W | 27-48 |
| NCAAF FCS | 2018/11/03 19:00 | Nicholls State v Houston Christian | W | 41-20 |
| NCAAF | 2017/11/04 20:30 | Nicholls State v Houston Christian | W | 23-17 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | L | 21-38 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | L | 58-48 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | W | 17-48 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | W | 14-31 |
| NCAAF | 2021/09/11 23:00 | Nicholls State v Lafayette | L | 24-27 |
| NCAAF | 2021/09/04 23:00 | Nicholls State v Memphis | L | 17-42 |
| NCAAF | 2021/04/10 20:00 | SE Louisiana v Nicholls State | L | 52-45 |
| NCAAF | 2021/04/03 17:00 | Nicholls State v McNeese State | L | 31-43 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | L | 24-61 |
| NCAAF | 2021/10/09 23:00 | Northwestern State v Houston Christian | L | 21-17 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | L | 17-48 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | L | 27-37 |
| NCAAF | 2021/09/11 23:00 | Northern Colorado v Houston Christian | L | 45-13 |
| NCAAF | 2021/09/03 00:00 | Houston Christian v New Mexico | L | 17-27 |
| NCAAF | 2020/10/03 19:00 | Houston Christian v Eastern Kentucky | W | 33-30 |
| NCAAF | 2020/09/26 23:00 | Houston Christian v Louisiana Tech | L | 38-66 |