[17] Mississippi 31-21 Mississippi State [51] 2021-11-26 00:30
Stadium: Davis Wade Stadium at Scott Field Round: 1
Home Manager: Mike Leach Away Manager: Lane Kiffin
Head to Head
| NCAAF | 2020/11/28 21:00 | Mississippi State v Mississippi | W | 24-31 |
| NCAAF | 2019/11/29 00:30 | Mississippi v Mississippi State | L | 20-21 |
| NCAAF | 2018/11/23 00:30 | Mississippi State v Mississippi | L | 35-3 |
| NCAAF | 2017/11/24 00:30 | Mississippi v Mississippi State | W | 31-28 |
| NCAAF | 2016/11/26 20:30 | Mississippi State v Mississippi | L | 55-20 |
| NCAAF | 2015/11/29 00:15 | Mississippi State v Mississippi | W | 27-38 |
| NCAAF | 2014/11/29 20:30 | Mississippi v Mississippi State | W | 31-17 |
| NCAAF | 2012/11/24 12:00 | Mississippi v Mississippi State | W | 41-24 |
Home History
| NCAAF | 2021/11/21 00:30 | Vanderbilt v Mississippi | W | 17-31 |
| NCAAF | 2021/11/14 00:00 | Texas A&M v Mississippi | W | 19-29 |
| NCAAF | 2021/11/06 16:00 | Liberty v Mississippi | W | 14-27 |
| NCAAF | 2021/10/30 23:00 | Mississippi v Auburn | L | 20-31 |
| NCAAF | 2021/10/23 19:30 | LSU v Mississippi | W | 17-31 |
| NCAAF | 2021/10/16 23:30 | Mississippi v Tennessee | W | 31-26 |
| NCAAF | 2021/10/09 16:00 | Arkansas v Mississippi | W | 51-52 |
| NCAAF | 2021/10/02 19:30 | Mississippi v Alabama | L | 21-42 |
Away History
| NCAAF | 2021/11/20 17:00 | Tennessee State v Mississippi State | W | 10-55 |
| NCAAF | 2021/11/13 17:00 | Mississippi State v Auburn | W | 43-34 |
| NCAAF | 2021/11/06 20:00 | Mississippi State v Arkansas | L | 28-31 |
| NCAAF | 2021/10/30 23:00 | Kentucky v Mississippi State | W | 17-31 |
| NCAAF | 2021/10/23 20:00 | Mississippi State v Vanderbilt | W | 45-6 |
| NCAAF | 2021/10/16 23:00 | Alabama v Mississippi State | L | 49-9 |
| NCAAF | 2021/10/02 23:00 | Mississippi State v Texas A&M | W | 26-22 |
| NCAAF | 2021/09/25 16:00 | LSU v Mississippi State | L | 28-25 |