[15] Leyton Orient 0-1 Colchester [21] 2022-02-05 15:00
Stadium: Matchroom Stadium Round: 30
Referee: Tom Reeves Home Manager: Kenneth Francis Jackett Away Manager: Wayne Brown
Head to Head
| England League 2 | 2021/02/06 15:00 | Leyton Orient v Colchester | D | 0-0 |
| England League 2 | 2020/11/14 15:00 | Colchester v Leyton Orient | L | 2-1 |
| England League 2 | 2019/12/26 13:00 | Leyton Orient v Colchester | L | 1-3 |
| England League 2 | 2019/09/21 14:00 | Colchester v Leyton Orient | L | 2-1 |
| England League 2 | 2017/04/29 14:00 | Leyton Orient v Colchester | L | 1-3 |
| England League 2 | 2016/11/12 15:00 | Colchester v Leyton Orient | W | 0-3 |
| World Club Friendlies | 2015/07/25 14:00 | Colchester v Leyton Orient | W | 0-3 |
| England League 1 | 2015/01/24 15:00 | Colchester v Leyton Orient | L | 2-0 |
Home History
| England League 2 | 2022/02/01 19:45 | Bradford v Leyton Orient | D | 1-1 |
| England League 2 | 2022/01/29 15:00 | Mansfield v Leyton Orient | L | 2-0 |
| England League 2 | 2022/01/25 19:45 | Leyton Orient v Newport County | L | 0-1 |
| England League 2 | 2022/01/22 15:00 | Leyton Orient v Port Vale | D | 0-0 |
| England FA Cup | 2022/01/09 14:00 | Stoke v Leyton Orient | L | 2-0 |
| England League 2 | 2021/12/18 15:00 | Tranmere v Leyton Orient | L | 1-0 |
| England League 2 | 2021/12/11 15:00 | Leyton Orient v Crawley Town | L | 1-2 |
| England League 2 | 2021/12/07 19:45 | Leyton Orient v Swindon | W | 4-1 |
Away History
| England League 2 | 2022/02/01 19:45 | Colchester v Rochdale | D | 1-1 |
| England League 2 | 2022/01/29 15:00 | Colchester v Swindon | D | 1-1 |
| England League 2 | 2022/01/22 15:00 | Salford City v Colchester | W | 0-3 |
| England League 2 | 2022/01/18 19:45 | Sutton Utd v Colchester | L | 3-2 |
| England League 2 | 2022/01/15 15:00 | Colchester v Barrow | L | 0-2 |
| England League 2 | 2022/01/11 19:45 | Forest Green v Colchester | L | 2-0 |
| England EFL Trophy | 2022/01/04 19:45 | Sutton Utd v Colchester | L | 2-1 |
| England League 2 | 2022/01/01 15:00 | Crawley Town v Colchester | L | 3-1 |