[2] Ghana 1-0 South Africa [1] 2021-11-14 19:00
Round: 1
Home Manager: Charles Kwablan Akonnor Away Manager: Hugo Broos
Head to Head
| Africa - World Cup Qualifying | 2021/09/06 16:00 | South Africa v Ghana | L | 1-0 |
| Africa Cup of Nations Qualification | 2021/03/25 16:00 | South Africa v Ghana | D | 1-1 |
| Africa Cup of Nations Qualification | 2019/11/14 19:00 | Ghana v South Africa | W | 2-0 |
| International Match | 2019/06/15 13:30 | Ghana v South Africa | D | 0-0 |
| International Match | 2016/10/11 17:00 | South Africa v Ghana | D | 1-1 |
Home History
| Africa - World Cup Qualifying | 2021/11/11 13:00 | Ethiopia v Ghana | D | 1-1 |
| Africa - World Cup Qualifying | 2021/10/12 13:00 | Zimbabwe v Ghana | W | 0-1 |
| Africa - World Cup Qualifying | 2021/10/09 16:00 | Ghana v Zimbabwe | W | 3-1 |
| Africa - World Cup Qualifying | 2021/09/06 16:00 | South Africa v Ghana | L | 1-0 |
| Africa - World Cup Qualifying | 2021/09/03 19:00 | Ghana v Ethiopia | W | 1-0 |
| International Match | 2021/06/12 17:00 | Ghana v Ivory Coast | D | 0-0 |
| International Match | 2021/06/08 19:00 | Morocco v Ghana | L | 1-0 |
| Africa Cup of Nations Qualification | 2021/03/28 16:00 | Ghana v Sao Tome e Principe | W | 3-1 |
Away History
| Africa - World Cup Qualifying | 2021/11/11 19:00 | South Africa v Zimbabwe | W | 1-0 |
| Africa - World Cup Qualifying | 2021/10/12 16:00 | South Africa v Ethiopia | W | 1-0 |
| Africa - World Cup Qualifying | 2021/10/09 13:00 | Ethiopia v South Africa | W | 1-3 |
| Africa - World Cup Qualifying | 2021/09/06 16:00 | South Africa v Ghana | W | 1-0 |
| Africa - World Cup Qualifying | 2021/09/03 13:00 | Zimbabwe v South Africa | D | 0-0 |
| COSAFA Cup | 2021/07/18 13:30 | South Africa v Senegal | W | 5-4 |
| COSAFA Cup | 2021/07/16 15:00 | South Africa v Mozambique | W | 3-0 |
| COSAFA Cup | 2021/07/14 13:00 | South Africa v Zambia | D | 0-0 |