Stadium: Fitton Field Round: 1
Home Manager: Bob Chesney Away Manager: John Garrett
| NCAAF | 2019/11/09 17:00 | Lafayette v Holy Cross | W | 23-20 |
| NCAAF FCS | 2018/11/03 16:30 | Holy Cross v Lafayette | L | 40-14 |
| NCAAF | 2017/09/30 17:05 | Holy Cross v Lafayette | W | 7-10 |
| NCAAF | 2021/11/04 23:30 | Georgia State v Lafayette | W | 17-21 |
| NCAAF | 2021/10/30 16:30 | Lafayette v Georgetown | W | 24-23 |
| NCAAF | 2021/10/30 16:00 | Texas State v Lafayette | W | 0-45 |
| NCAAF | 2021/10/21 23:30 | Lafayette v Arkansas State | W | 28-27 |
| NCAAF | 2021/10/16 17:00 | Lafayette v Harvard | L | 3-30 |
| NCAAF | 2021/10/12 23:30 | Appalachian St v Lafayette | W | 13-41 |
| NCAAF | 2021/10/09 16:30 | Bucknell v Lafayette | W | 0-27 |
| NCAAF | 2021/10/03 00:00 | Lafayette v South Alabama | W | 20-18 |
| NCAAF | 2021/10/30 16:00 | Holy Cross v Lehigh | W | 31-12 |
| NCAAF | 2021/10/23 21:00 | Colgate v Holy Cross | W | 10-42 |
| NCAAF | 2021/10/16 17:30 | Georgetown v Holy Cross | W | 14-48 |
| NCAAF | 2021/10/02 17:30 | Harvard v Holy Cross | L | 38-13 |
| NCAAF | 2021/09/25 17:00 | Holy Cross v Monmouth | W | 45-15 |
| NCAAF | 2021/09/18 16:00 | Holy Cross v Yale | W | 20-17 |
| NCAAF | 2021/09/11 18:00 | Merrimack v Holy Cross | L | 35-21 |
| NCAAF | 2021/09/04 16:00 | Holy Cross v Connecticut | W | 38-28 |