Stadium: DeGol Field Round: 1
Home Manager: Chris Villarrial Away Manager: Dan Curran
| NCAAF | 2021/11/06 16:00 | Merrimack v Wagner | W | 35-26 |
| NCAAF | 2021/10/30 17:00 | Central Connecticut v Merrimack | L | 49-21 |
| NCAAF | 2021/10/16 16:00 | Merrimack v LIU Brooklyn | W | 43-5 |
| NCAAF | 2021/10/09 18:00 | Merrimack v Sacred Heart | L | 10-20 |
| NCAAF | 2021/10/02 17:00 | Duquesne v Merrimack | L | 37-14 |
| NCAAF | 2021/09/25 18:00 | Merrimack v Delaware State | W | 47-10 |
| NCAAF | 2021/09/18 16:00 | Merrimack v Maine | L | 26-31 |
| NCAAF | 2021/09/11 18:00 | Merrimack v Holy Cross | W | 35-21 |
| NCAAF | 2021/11/06 16:00 | Sacred Heart v St.Francis (PA) | L | 14-13 |
| NCAAF | 2021/10/30 19:00 | St.Francis (PA) v Duquesne | W | 17-10 |
| NCAAF | 2021/10/16 16:00 | St.Francis (PA) v Bryant | L | 17-18 |
| NCAAF | 2021/10/09 17:00 | LIU Brooklyn v St.Francis (PA) | W | 10-55 |
| NCAAF | 2021/10/02 16:00 | St.Francis (PA) v Morgan State | W | 27-14 |
| NCAAF | 2021/09/25 16:00 | Norfolk State v St.Francis (PA) | L | 28-16 |
| NCAAF | 2021/09/18 16:00 | Wagner v St.Francis (PA) | W | 24-39 |
| NCAAF | 2021/09/11 22:00 | St.Francis (PA) v Delaware | L | 10-27 |