Stadium: Bailey Memorial Stadium Round: 1
| NCAAF | 2021/10/16 17:00 | St.Thomas MIN v Stetson Hatters | L | 38-7 |
| NCAAF | 2021/10/09 16:00 | Stetson Hatters v Marist | L | 3-34 |
| NCAAF | 2021/10/02 17:00 | Davidson Wildcats v Stetson Hatters | L | 35-28 |
| NCAAF | 2021/09/25 17:00 | Stetson Hatters v Princeton | L | 0-63 |
| NCAAF | 2021/09/11 22:00 | Stetson Hatters v Ave Maria Gyrenes | W | 49-16 |
| NCAAF | 2021/09/04 22:00 | Stetson Hatters v Warner Royals | W | 54-14 |
| NCAAF | 2021/04/10 20:00 | Stetson Hatters v San Diego | L | 10-34 |
| NCAAF | 2021/04/03 17:00 | Presbyterian v Stetson Hatters | L | 26-3 |
| NCAAF | 2021/10/23 17:00 | San Diego v Presbyterian | L | 69-28 |
| NCAAF | 2021/10/16 23:00 | Presbyterian v Davidson Wildcats | L | 35-70 |
| NCAAF | 2021/10/09 17:00 | Morehead State v Presbyterian | L | 38-30 |
| NCAAF | 2021/09/25 17:00 | Presbyterian v Dayton | L | 43-63 |
| NCAAF | 2021/09/18 22:00 | Presbyterian v Campbell | L | 0-72 |
| NCAAF | 2021/09/11 20:00 | Presbyterian v Fort Lauderdale Soaring Eagles | W | 68-3 |
| NCAAF | 2021/09/04 20:00 | Presbyterian v St. Andrews Knights | W | 84-43 |
| NCAAF | 2021/04/17 18:00 | Presbyterian v Drake Bulldogs | W | 28-24 |