[5] Harlequins 41-27 Northampton [4] 2021-12-27 17:00
Stadium: London Round: 11
Referee: Wayne Barnes
Head to Head
| Premiership Rugby Cup | 2021/11/19 19:45 | Harlequins v Northampton | W | 26-25 |
| Premiership Rugby | 2021/03/07 15:00 | Harlequins v Northampton | W | 37-19 |
| Premiership Rugby | 2020/11/28 14:00 | Northampton v Harlequins | W | 29-49 |
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | W | 30-17 |
| Premiership Rugby | 2019/11/01 19:45 | Northampton v Harlequins | L | 40-22 |
| Premiership Rugby | 2019/04/13 14:00 | Harlequins v Northampton | L | 19-20 |
| Premiership Rugby | 2018/09/07 18:45 | Northampton v Harlequins | L | 25-18 |
| LV Cup | 2018/02/02 19:45 | Northampton v Harlequins | L | 36-10 |
Home History
| European Rugby Champions Cup | 2021/12/18 13:00 | Harlequins v Cardiff Blues | W | 43-17 |
| European Rugby Champions Cup | 2021/12/12 17:30 | Castres v Harlequins | W | 18-20 |
| Premiership Rugby | 2021/12/05 15:00 | Leicester v Harlequins | L | 16-14 |
| Premiership Rugby | 2021/11/27 15:00 | Harlequins v London Irish | L | 19-22 |
| Premiership Rugby Cup | 2021/11/19 19:45 | Harlequins v Northampton | W | 26-25 |
| Premiership Rugby Cup | 2021/11/13 14:30 | Saracens v Harlequins | L | 28-21 |
| Premiership Rugby | 2021/11/07 16:30 | Wasps v Harlequins | W | 16-26 |
| Premiership Rugby | 2021/10/31 15:00 | Harlequins v Saracens | L | 22-29 |
Away History
| European Rugby Champions Cup | 2021/12/17 20:00 | Ulster v Northampton | L | 27-22 |
| European Rugby Champions Cup | 2021/12/10 20:00 | Northampton v Racing Metro | L | 14-45 |
| Premiership Rugby | 2021/12/04 15:00 | Northampton v Bath | W | 40-19 |
| Premiership Rugby | 2021/11/26 19:45 | Bristol v Northampton | W | 20-36 |
| Premiership Rugby Cup | 2021/11/19 19:45 | Harlequins v Northampton | L | 26-25 |
| Premiership Rugby Cup | 2021/11/13 15:30 | Northampton v London Irish | L | 26-36 |
| Premiership Rugby | 2021/11/06 17:00 | Sale Sharks v Northampton | L | 30-6 |
| Premiership Rugby | 2021/10/30 14:00 | Northampton v Leicester | L | 26-55 |