[2] Lyon Women 5-0 SL Benfica Women [3] 2021-10-14 19:00
Stadium: Stade Municipal de Gerland Round: 2
Home History
| UEFA Champions League Women | 2021/10/05 16:45 | BK Hacken Women v Lyon Women | W | 0-3 |
| France Division 1 Women | 2021/10/01 19:00 | Bordeaux Women v Lyon Women | W | 1-4 |
| France Division 1 Women | 2021/09/24 16:30 | Lyon Women v Guingamp Women | W | 4-0 |
| France Division 1 Women | 2021/09/12 13:05 | Lyon Women v Dijon Women | W | 6-0 |
| UEFA Champions League Women | 2021/09/08 16:00 | Lyon Women v Levante UD Women | W | 2-1 |
| France Division 1 Women | 2021/09/05 11:00 | Lyon Women v St Etienne Women | W | 6-0 |
| UEFA Champions League Women | 2021/09/01 19:00 | Levante UD Women v Lyon Women | W | 1-2 |
| France Division 1 Women | 2021/08/27 16:30 | Lyon Women v Reims Women | W | 3-0 |
Away History
| Portugal Campeonato Nacional Women | 2021/10/09 10:00 | Maritimo Women v Benfica Women | W | 2-3 |
| UEFA Champions League Women | 2021/10/05 19:00 | Benfica Women v Bayern Munich Women | D | 0-0 |
| Portugal Campeonato Nacional Women | 2021/10/02 15:45 | Benfica Women v Amora Women | W | 5-0 |
| Portugal Campeonato Nacional Women | 2021/09/26 16:00 | Sporting Women v Benfica Women | L | 5-1 |
| UEFA Champions League Women | 2021/09/09 18:00 | Benfica Women v FC Twente Women | W | 4-0 |
| Portugal Campeonato Nacional Women | 2021/09/05 15:00 | Benfica Women v CA Ouriense Women | W | 3-2 |
| UEFA Champions League Women | 2021/08/31 17:30 | FC Twente Women v Benfica Women | D | 1-1 |
| Portugal Women Super Cup | 2021/08/28 16:30 | Benfica Women v Sporting Women | L | 0-2 |