Stadium: Cancha Central Round: 27 Ground: Clay
| Challenger Montevideo MD | 2021/11/11 01:05 | Cerundolo/Cuevas v Klier Junior/P De Almeida | 6-3,6-2 |
| Challenger Buenos Aires MD | 2021/10/20 21:10 | Matos/M R Alves v Cerundolo/Cuevas | 6-2,7-5 |
| Challenger Montevideo MD | 2021/11/09 20:10 | Collarini/Duran v Cachin/Ugo Carabelli | 1-6,6-4,10-8 |