Stadium: Smith-Hammond-Middleton Memorial Center
Home Manager: Tony Madlock Away Manager: Brian Collins
| NCAAB | 2021/12/17 01:00 | Tennessee State v Charleston Southern | W | 78-75 |
| NCAAB | 2021/12/12 22:00 | Tennessee State v Lipscomb | W | 73-65 |
| NCAAB | 2021/12/11 00:00 | IUPUI v Tennessee State | W | 44-70 |
| NCAAB | 2021/12/04 22:00 | Tennessee State v Chicago St | L | 49-59 |
| NCAAB | 2021/11/28 20:00 | Southern v Tennessee State | L | 82-80 |
| NCAAB | 2021/11/24 02:00 | Tennessee State v Nebraska | L | 73-79 |
| NCAAB | 2021/11/22 01:00 | Tennessee State v South Dakota | L | 66-83 |
| NCAAB | 2021/11/17 01:00 | Tennessee State v Fisk | W | 111-56 |
| NCAAB | 2021/12/17 00:00 | South Carolina State v Carver | W | 105-46 |
| NCAAB | 2021/12/15 01:00 | South Carolina State v Duke | L | 62-103 |
| NCAAB | 2021/12/11 00:00 | High Point v South Carolina State | W | 66-67 |
| NCAAB | 2021/12/04 00:00 | South Carolina State v South Florida | W | 65-64 |
| NCAAB | 2021/11/28 19:00 | The Citadel v South Carolina State | L | 91-79 |
| NCAAB | 2021/11/24 00:00 | USC Upstate v South Carolina State | L | 82-78 |
| NCAAB | 2021/11/19 01:00 | South Carolina State v St. Andrew's | W | 67-53 |
| NCAAB | 2021/11/17 00:00 | South Carolina State v Georgia Bulldogs | L | 60-76 |