Stadium: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Dewayne Alexander
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | W | 17-28 |
| NCAAF | 2021/03/28 19:00 | Tennessee Tech v SE Missouri St | L | 21-24 |
| NCAAF | 2019/10/05 23:00 | Tennessee Tech v SE Missouri St | L | 37-43 |
| NCAAF | 2018/10/06 23:00 | SE Missouri St v Tennessee Tech | L | 70-38 |
| NCAAF | 2017/10/14 18:00 | SE Missouri St v Tennessee Tech | L | 31-3 |
| NCAAF | 2022/10/01 19:00 | Tennessee Tech v Tennessee Martin | L | 28-45 |
| NCAAF | 2022/09/17 23:00 | Samford v Tennessee Tech | L | 33-28 |
| NCAAF | 2022/09/10 23:00 | Texas A&M-Commerce v Tennessee Tech | W | 25-26 |
| NCAAF | 2022/09/03 00:00 | Tennessee Tech v Kansas | L | 10-56 |
| NCAAF | 2021/11/20 20:00 | Tennessee Tech v Austin Peay | L | 20-48 |
| NCAAF | 2021/11/13 19:30 | Tennessee Martin v Tennessee Tech | L | 42-3 |
| NCAAF | 2021/11/06 18:00 | Tennessee Tech v Murray State | L | 27-32 |
| NCAAF | 2021/10/23 18:30 | Tennessee Tech v Lynchburg Dragons | W | 56-13 |
| NCAAF | 2022/10/01 18:00 | SE Missouri St v Lindenwood | W | 49-28 |
| NCAAF | 2022/09/24 19:00 | Central Arkansas v SE Missouri St | W | 27-35 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | W | 16-42 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | W | 34-31 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | L | 10-42 |
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | W | 14-31 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | L | 10-28 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |