[5] North Carolina 38-35 Duke [4] 2022-10-16 00:00
Stadium: Brooks Field at Wallace Wade Stadium Round: 1
Home Manager: Mike Elko Away Manager: Mack Brown
Head to Head
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | W | 7-38 |
| NCAAF | 2020/11/07 17:00 | North Carolina v Duke | W | 56-24 |
| NCAAF | 2019/10/26 20:00 | Duke v North Carolina | W | 17-20 |
| NCAAF | 2018/11/10 17:20 | North Carolina v Duke | L | 35-42 |
| NCAAF | 2017/09/23 19:30 | Duke v North Carolina | L | 27-17 |
| NCAAF | 2016/11/11 00:30 | North Carolina v Duke | L | 27-28 |
| NCAAF | 2015/11/07 17:00 | North Carolina v Duke | W | 66-31 |
| NCAAF | 2014/11/21 00:30 | Duke v North Carolina | W | 20-45 |
Home History
| NCAAF | 2022/10/08 20:00 | North Carolina v Miami Florida | W | 27-24 |
| NCAAF | 2022/10/01 19:30 | Virginia Tech v North Carolina | W | 10-41 |
| NCAAF | 2022/09/24 19:30 | Notre Dame v North Carolina | L | 45-32 |
| NCAAF | 2022/09/10 16:00 | North Carolina v Georgia State | W | 35-28 |
| NCAAF | 2022/09/03 16:00 | North Carolina v Appalachian St | W | 63-61 |
| NCAAF | 2022/08/28 00:15 | Florida A&M v North Carolina | W | 24-56 |
| NCAAF Bowl Games | 2021/12/30 16:30 | South Carolina v North Carolina | L | 38-21 |
| NCAAF | 2021/11/27 00:00 | North Carolina v NC State | L | 30-34 |
Away History
| NCAAF | 2022/10/08 20:00 | Duke v Georgia Tech | L | 20-23 |
| NCAAF | 2022/10/01 23:30 | Virginia v Duke | W | 17-38 |
| NCAAF | 2022/09/24 16:00 | Duke v Kansas | L | 27-35 |
| NCAAF | 2022/09/17 22:00 | North Carolina A&T v Duke | W | 20-49 |
| NCAAF | 2022/09/10 16:00 | Duke v Northwestern | W | 31-23 |
| NCAAF | 2022/09/02 23:30 | Temple v Duke | W | 0-30 |
| NCAAF | 2021/11/27 17:30 | Miami Florida v Duke | L | 47-10 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | L | 62-22 |