Stadium: Rice-Totten Stadium Round: 1
Home Manager: Vincent Dancy Away Manager: Bubba McDowell
| NCAAF | 2022/11/12 20:00 | Prairie View v Arkansas Pine Bluff | W | 55-24 |
| NCAAF | 2022/11/04 23:30 | Alcorn State v Prairie View | L | 23-16 |
| NCAAF | 2022/10/29 19:00 | Bethune Cookman v Prairie View | W | 48-58 |
| NCAAF | 2022/10/22 21:00 | Prairie View v Lamar | W | 54-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | L | 45-13 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | W | 34-14 |
| NCAAF | 2022/09/24 22:00 | Prairie View v Alabama State | W | 25-15 |
| NCAAF | 2022/09/17 23:00 | Incarnate Word v Prairie View | L | 31-14 |
| NCAAF | 2022/11/12 20:00 | Southern v Mississippi Valley State | L | 27-7 |
| NCAAF | 2022/11/03 23:30 | Alabama v Mississippi Valley State | W | 20-30 |
| NCAAF | 2022/10/22 20:00 | Bethune Cookman v Mississippi Valley State | L | 45-35 |
| NCAAF | 2022/10/15 19:00 | Mississippi Valley State v Alabama State | L | 9-24 |
| NCAAF | 2022/10/08 23:00 | Alcorn State v Mississippi Valley State | L | 30-7 |
| NCAAF | 2022/10/01 22:00 | Mississippi Valley State v Florida A&M | L | 7-34 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | L | 7-49 |
| NCAAF | 2022/09/17 23:00 | Mississippi Valley State v Delta State | L | 17-28 |