Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2021/09/19 00:00 | Central Oklahoma v Missouri Southern Lions | W | 10-14 |
| NCAAF | 2019/11/02 18:00 | Central Oklahoma v Missouri Southern Lions | L | 52-27 |
| NCAAF | 2018/10/27 19:00 | Missouri Southern Lions v Central Oklahoma | L | 0-31 |
| NCAAF | 2022/09/10 23:00 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 |
| NCAAF | 2022/09/02 00:00 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 |
| NCAAF | 2021/11/13 19:00 | Washburn Ichabods Football v Missouri Southern Lions | L | 38-28 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | L | 7-49 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 |
| NCAAF | 2021/10/23 19:00 | Emporia State v Missouri Southern Lions | L | 24-21 |
| NCAAF | 2021/10/16 21:00 | Missouri Southern Lions v Central Missouri Mules | W | 30-28 |
| NCAAF | 2021/10/09 19:00 | Blue Tigers v Missouri Southern Lions | W | 32-52 |
| NCAAF | 2022/09/09 00:00 | Central Oklahoma v Emporia State | W | 21-13 |
| NCAAF | 2022/09/02 00:00 | Missouri Western Griffons v Central Oklahoma | L | 35-0 |
| NCAAF | 2021/11/13 19:00 | Central Missouri Mules v Central Oklahoma | L | 30-29 |
| NCAAF | 2021/11/06 19:00 | Nebraska Kearney v Central Oklahoma | L | 37-22 |
| NCAAF | 2021/10/30 18:00 | Pittsburgh State Gorillas v Central Oklahoma | L | 26-20 |
| NCAAF | 2021/10/23 19:00 | Central Oklahoma v Washburn Ichabods Football | L | 17-29 |
| NCAAF | 2021/10/17 00:00 | Fort Hays State University Tigers v Central Oklahoma | W | 14-24 |
| NCAAF | 2021/10/08 00:00 | Northeastern State Riverhawks v Central Oklahoma | W | 9-49 |