| Colombia Regional League | 2022/10/09 19:00 | CD Gallegol v E.D.P IND. Medellin | D | 0-0 |
| Colombia Regional League | 2022/10/03 16:21 | E.D.P IND. Medellin v Independiente Sabaneta | W | 4-0 |
| Colombia Regional League | 2022/09/24 21:27 | FC Leones Reserves v E.D.P IND. Medellin | W | 0-2 |
| Colombia Regional League | 2022/08/29 16:21 | E.D.P IND. Medellin v Deportivo Alexis Garcia | D | 1-1 |
| Colombia Regional League | 2022/08/17 16:10 | Independiente Sabaneta v E.D.P IND. Medellin | W | 1-4 |
| Colombia Regional League | 2022/08/11 12:00 | Molino Viejo v E.D.P IND. Medellin | D | 1-1 |
| Colombia Regional League | 2022/07/10 17:36 | E.D.P IND. Medellin v Talento y Vida | D | 1-1 |
| Colombia Regional League | 2022/07/05 15:23 | Medellin City FC v E.D.P IND. Medellin | L | 4-1 |
| Colombia Regional League | 2022/10/12 17:00 | Universidad de Antioquia v Sol de Oriente | L | 0-2 |
| Colombia Regional League | 2022/09/19 16:23 | Universidad de Antioquia v Independiente Sabaneta | L | 1-3 |
| Colombia Regional League | 2022/08/02 19:17 | Medellin City FC v Universidad de Antioquia | W | 0-1 |
| Colombia Regional League | 2022/07/18 17:19 | Aguilas Doradas Reserves v Universidad de Antioquia | D | 1-1 |
| Colombia Regional League | 2022/05/21 17:21 | Universidad de Antioquia v Ferrovalvulas FC | L | 1-2 |
| Colombia Regional League | 2022/05/10 17:13 | Universidad de Antioquia v Atletico Nacional Medellin Reserves | L | 0-1 |
| Colombia Regional League | 2022/04/08 15:12 | FC Leones Reserves v Universidad de Antioquia | L | 3-2 |
| Colombia Regional League | 2022/03/21 17:18 | Deportivo Alexis Garcia v Universidad de Antioquia | L | 3-0 |