[9] John Isner 7-6,7-6 Ryan Harrison [59] 2018-05-09 14:25
Stadium: Pista 5 Round: 25 Ground: Clay
Head to Head
| ATP Acapulco | 2018/02/27 01:00 | John Isner v Ryan Harrison | 3-6,6-7 |
| ATP Atlanta | 2017/07/30 21:00 | Ryan Harrison v John Isner | 6-7,6-7 |
Home History
| ATP Houston | 2018/04/14 00:10 | John Isner v Steve Johnson | 6-7,6-4,6-7 |
| ATP Houston | 2018/04/12 23:00 | John Isner v Henri Laaksonen | 6-4,6-2 |
| Davis Cup | 2018/04/06 21:00 | John Isner v Joris De Loore | 6-3,6-7,7-6,6-4 |
| ATP Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP Miami | 2018/03/30 17:00 | Juan Martin Del Potro v John Isner | 1-6,6-7 |
| ATP Miami | 2018/03/28 19:00 | Hyeon Chung v John Isner | 1-6,4-6 |
| ATP Miami | 2018/03/27 15:00 | John Isner v Marin Cilic | 7-6,6-3 |
| ATP Miami | 2018/03/25 21:25 | John Isner v Mikhail Youzhny | 6-4,6-3 |
Away History
| ATP Madrid | 2018/05/08 16:15 | Guillermo Garcia-Lopez v Ryan Harrison | 4-6,6-7 |
| ATP Houston | 2018/04/12 18:35 | Taylor Fritz v Ryan Harrison | 3-6,6-0,6-3 |
| ATP Houston | 2018/04/10 20:35 | Miomir Kecmanovic v Ryan Harrison | 4-6,3-6 |
| Davis Cup | 2018/04/08 19:00 | Ryan Harrison v Ruben Bemelmans | 6-3,6-4 |
| ATP Miami | 2018/03/21 15:00 | Ryan Harrison v Joao Sousa | 6-7,6-7 |
| ATP Indian Wells | 2018/03/09 01:05 | Ryan Harrison v Federico Delbonis | 2-6,6-4,5-7 |
| ATP Acapulco | 2018/03/01 23:30 | Ryan Harrison v Alexander Zverev | 4-6,1-6 |
| ATP Acapulco | 2018/02/28 23:30 | Ryan Harrison v Diego Schwartzman | 6-3,5-7,6-4 |