[15] Northwestern 20-29 Michigan State [97] 2020-11-28 20:30
Stadium: Spartan Stadium Round: 1
Head to Head
| NCAAF | 2019/09/21 16:00 | Michigan State v Northwestern | L | 31-10 |
| NCAAF | 2018/10/06 16:00 | Northwestern v Michigan State | W | 29-19 |
| NCAAF | 2017/10/28 19:30 | Michigan State v Northwestern | W | 31-39 |
| NCAAF | 2016/10/15 19:30 | Northwestern v Michigan State | W | 54-40 |
| NCAAF | 2012/11/17 12:00 | Michigan State v Northwestern | W | 20-23 |
| NCAAF | 2011/11/26 12:00 | Northwestern v Michigan State | L | 17-31 |
| NCAAF | 2010/10/23 12:00 | Northwestern v Michigan State | L | 27-35 |
| NCAAF | 2009/10/17 12:00 | Michigan State v Northwestern | L | 24-14 |
| NCAAF | 2008/10/11 12:00 | Northwestern v Michigan State | L | 20-37 |
| NCAAF | 2007/10/06 12:00 | Michigan State v Northwestern | W | 41-48 |
| NCAAF | 2006/10/21 12:00 | Northwestern v Michigan State | L | 38-41 |
| NCAAF | 2005/10/22 12:00 | Michigan State v Northwestern | W | 14-49 |
| NCAAF | 2002/09/28 12:00 | Michigan State v Northwestern | L | 39-24 |
| NCAAF | 2001/09/29 12:00 | Northwestern v Michigan State | W | 27-26 |
| NCAAF | 2000/09/30 12:00 | Michigan State v Northwestern | W | 17-37 |