[31] BUF Sabres 2-5 NY Islanders [6] 2021-03-07 17:00
Stadium: Nassau Veterans Memorial Coliseum
Home Manager: Barry Trotz Away Manager: Ralph Krueger
Head to Head
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | L | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | L | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL | 2019/12/14 18:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2019/11/02 23:00 | NY Islanders v BUF Sabres | L | 1-0 |
| NHL | 2019/03/30 23:00 | BUF Sabres v NY Islanders | L | 1-5 |
| NHL | 2019/02/13 00:00 | NY Islanders v BUF Sabres | W | 1-3 |
| NHL | 2018/12/31 23:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL Pre-Season | 2018/09/28 23:00 | BUF Sabres v NY Islanders | W | 5-4 |
| NHL | 2018/02/09 00:00 | NY Islanders v BUF Sabres | W | 3-4 |
| NHL | 2017/12/28 00:00 | BUF Sabres v NY Islanders | L | 2-3 |
| NHL | 2017/10/07 23:00 | NY Islanders v BUF Sabres | L | 6-3 |
| NHL Pre-Season | 2017/09/29 23:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL | 2017/04/02 19:00 | NY Islanders v BUF Sabres | L | 4-2 |
| NHL | 2016/12/24 00:00 | BUF Sabres v NY Islanders | L | 1-5 |
| NHL | 2016/12/17 00:00 | NY Islanders v BUF Sabres | W | 2-3 |