[7] America de Cali 0-1 Deportes Quindio [9] 2021-09-04 21:00
Stadium: Olimpico Pascual Guerrero Round: 8
Referee: Jorge Andres Tabares Cano Home Manager: Juan Carlos Osorio Arbelaez Away Manager: Oscar Hector Quintabani Faggionali
Head to Head
| Colombia Primera B | 2016/11/27 20:15 | America de Cali v Deportes Quindio | W | 2-1 |
| Colombia Primera B | 2016/10/26 00:45 | Deportes Quindio v America de Cali | L | 1-0 |
| Colombia Primera B | 2016/09/13 01:00 | Deportes Quindio v America de Cali | W | 0-1 |
| Colombia Primera B | 2016/04/26 01:00 | America de Cali v Deportes Quindio | W | 2-0 |
| Colombia Primera B | 2015/10/14 23:00 | Deportes Quindio v America de Cali | W | 0-2 |
| Colombia Primera B | 2015/05/18 20:15 | America de Cali v Deportes Quindio | D | 2-2 |
| Colombia Primera B | 2014/10/26 20:00 | America de Cali v Deportes Quindio | D | 0-0 |
| Colombia Cup | 2014/09/19 00:30 | Deportes Quindio v America de Cali | D | 0-0 |
| Colombia Cup | 2014/09/12 00:30 | America de Cali v Deportes Quindio | L | 0-1 |