[1] Guarani Asuncion 2-1 River Plate Asuncion [8] 2021-11-20 22:45
Stadium: Estadio Rogelio Silvino Livieres Round: 16
Referee: Mario Alberto Diaz De Vivar Home Manager: Fernando Jubero Carmona Away Manager: Ivan Almeida
Head to Head
| Paraguay Division Profesional | 2021/08/29 23:00 | River Plate Asuncion v Guarani Asuncion | W | 1-5 |
| Paraguay Division Profesional | 2021/04/12 23:00 | Guarani Asuncion v River Plate Asuncion | W | 2-0 |
| Paraguay Division Profesional | 2021/02/09 21:30 | River Plate Asuncion v Guarani Asuncion | W | 1-4 |
| Paraguay Division Profesional | 2020/11/01 21:15 | River Plate Asuncion v Guarani Asuncion | L | 1-0 |
| Paraguay Division Profesional | 2020/08/29 20:30 | River Plate Asuncion v Guarani Asuncion | L | 1-0 |
| Paraguay Division Profesional | 2020/08/05 22:30 | Guarani Asuncion v River Plate Asuncion | W | 3-0 |
| Paraguay Division Profesional | 2019/09/28 22:00 | River Plate Asuncion v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2019/07/12 23:30 | Guarani Asuncion v River Plate Asuncion | L | 1-3 |
| Paraguay Division Profesional | 2019/05/06 23:30 | River Plate Asuncion v Guarani Asuncion | W | 0-1 |
| Paraguay Division Profesional | 2019/03/04 21:45 | Guarani Asuncion v River Plate Asuncion | W | 2-1 |
| Paraguay Division Profesional | 2016/10/16 23:10 | River Plate Asuncion v Guarani Asuncion | W | 0-2 |
| Paraguay Division Profesional | 2016/07/20 21:00 | Guarani Asuncion v River Plate Asuncion | W | 2-0 |
| Paraguay Division Profesional | 2016/04/30 22:00 | Guarani Asuncion v River Plate Asuncion | W | 4-2 |
| Paraguay Division Profesional | 2016/02/27 21:30 | River Plate Asuncion v Guarani Asuncion | D | 1-1 |