[1] Penarol 3-1 IA Sud America [15] 2021-12-04 20:00
Stadium: Estadio Campeon del Siglo Round: 15
Referee: Gustavo Tejera Home Manager: Mauricio Larriera Away Manager: Luis Lopez
Head to Head
| Uruguay Apertura | 2021/08/22 18:00 | IA Sud America v Penarol | D | 1-1 |
| Uruguay Clausura | 2017/11/08 23:00 | IA Sud America v Penarol | W | 2-3 |
| Uruguay Apertura | 2017/04/01 20:00 | Penarol v IA Sud America | W | 4-0 |
| Uruguay Apertura | 2016/10/29 19:00 | IA Sud America v Penarol | W | 1-4 |
| Uruguay Clausura | 2016/03/05 23:00 | Penarol v IA Sud America | D | 1-1 |
| Uruguay Apertura | 2015/09/13 21:30 | IA Sud America v Penarol | W | 1-4 |
| Uruguay Clausura | 2015/03/21 19:00 | IA Sud America v Penarol | L | 1-0 |
| Uruguay Apertura | 2014/09/12 22:00 | Penarol v IA Sud America | D | 1-1 |