[7] Wake Forest 21-48 Louisville [14] 2022-10-29 19:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Dave Clawson
Head to Head
| NCAAF | 2021/10/02 16:30 | Louisville v Wake Forest | W | 34-37 |
| NCAAF | 2020/12/12 17:00 | Wake Forest v Louisville | L | 21-45 |
| NCAAF | 2019/10/12 23:30 | Louisville v Wake Forest | L | 62-59 |
| NCAAF | 2018/10/27 16:00 | Wake Forest v Louisville | W | 56-35 |
| NCAAF | 2017/10/28 16:20 | Louisville v Wake Forest | W | 32-42 |
| NCAAF | 2016/11/13 00:00 | Wake Forest v Louisville | L | 12-44 |
| NCAAF | 2015/10/30 23:00 | Wake Forest v Louisville | L | 19-20 |
| NCAAF | 2014/09/27 19:30 | Louisville v Wake Forest | L | 20-10 |
| NCAAF Bowl Games | 2007/01/02 12:00 | Louisville v Wake Forest | L | 24-13 |