[4] Santos Laguna 4-1 Club America [2] 2018-05-11 00:30
Weather: Good Stadium: Estadio TSM Corona Pitch: Good Round: 2
Referee: Cesar Arturo Ramos Palazuelos Home Manager: Robert Siboldi Away Manager: Miguel Herrera
Head to Head
| Mexico Liga MX | 2018/04/29 02:00 | Club America v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2017/11/20 00:30 | Santos Laguna v Club America | L | 0-1 |
| Europe Friendlies | 2017/07/06 01:30 | Club America v Santos Laguna | L | 3-2 |
| Mexico Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | W | 2-1 |
| Mexico Cup | 2017/03/02 02:30 | Santos Laguna v Club America | W | 2-1 |
| Mexico Cup | 2017/01/19 02:30 | Club America v Santos Laguna | L | 3-2 |
| Mexico Liga MX | 2016/10/30 02:00 | Club America v Santos Laguna | L | 3-1 |
| CONCACAF Champions Cup | 2016/04/06 02:00 | Club America v Santos Laguna | L | 1-0 |
| CONCACAF Champions Cup | 2016/03/17 02:00 | Santos Laguna v Club America | D | 0-0 |
| Mexico Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2015/08/15 02:30 | Santos Laguna v Club America | L | 0-2 |
| Mexico Liga MX | 2015/03/14 23:00 | Club America v Santos Laguna | L | 1-0 |
| Mexico Liga MX | 2014/09/27 02:30 | Santos Laguna v Club America | L | 1-4 |
| Mexico Liga MX | 2014/05/04 02:00 | Santos Laguna v Club America | W | 3-1 |
| Mexico Liga MX | 2014/05/01 01:00 | Club America v Santos Laguna | L | 5-3 |