[9] John Isner 1-6,4-6 Roger Federer [5] 2019-03-31 17:00
Stadium: Stadium Round: 29 Ground: Hardcourt outdoor
Head to Head
| Laver Cup | 2018/09/23 19:00 | Roger Federer v John Isner | 6-7,7-6,10-7 |
| Laver Cup | 2018/09/23 18:30 | Roger Federer v John Isner | 6-7,7-6,1-0 |
| US Open | 2015/09/08 01:00 | John Isner v Roger Federer | 6-7,6-7,5-7 |
Home History
| ATP Miami | 2019/03/29 17:00 | John Isner v Felix Auger Aliassime | 7-6,7-6 |
| ATP Miami | 2019/03/27 20:20 | Roberto Bautista-Agut v John Isner | 6-7,6-7 |
| ATP Miami | 2019/03/26 16:00 | Kyle Edmund v John Isner | 6-7,6-7 |
| ATP Miami | 2019/03/24 16:00 | Albert Ramos-Vinolas v John Isner | 5-7,6-7 |
| ATP Miami | 2019/03/22 18:25 | Lorenzo Sonego v John Isner | 6-7,6-7 |
| ATP Indian Wells | 2019/03/13 21:10 | John Isner v Karen Khachanov | 4-6,6-7 |
| ATP Indian Wells | 2019/03/12 21:20 | John Isner v Guido Pella | 6-3,6-4 |
| ATP Indian Wells | 2019/03/10 23:15 | John Isner v Alexei Popyrin | 6-0,6-2 |
Away History
| ATP Miami | 2019/03/29 23:00 | Roger Federer v Denis Shapovalov | 6-2,6-4 |
| ATP Miami | 2019/03/28 23:40 | Kevin Anderson v Roger Federer | 0-6,4-6 |
| ATP Miami | 2019/03/27 19:00 | Daniil Medvedev v Roger Federer | 4-6,2-6 |
| ATP Miami | 2019/03/25 19:35 | Filip Krajinovic v Roger Federer | 5-7,3-6 |
| ATP Miami | 2019/03/23 21:35 | Radu Albot v Roger Federer | 6-4,5-7,3-6 |
| ATP Indian Wells | 2019/03/17 22:35 | Dominic Thiem v Roger Federer | 3-6,6-3,7-5 |
| ATP Indian Wells | 2019/03/15 18:00 | Hubert Hurkacz v Roger Federer | 4-6,4-6 |
| ATP Indian Wells | 2019/03/13 21:10 | Kyle Edmund v Roger Federer | 1-6,4-6 |