Stadium: Fred G. Hughes Stadium Round: 1
| NCAAF | 2022/11/05 18:30 | NW Missouri State v Missouri Southern Lions | L | 27-5 |
| NCAAF | 2021/11/06 19:00 | Missouri Southern Lions v NW Missouri State | L | 7-49 |
| NCAAF | 2019/09/21 23:00 | Missouri Southern Lions v NW Missouri State | L | 34-66 |
| NCAAF | 2018/09/15 18:30 | NW Missouri State v Missouri Southern Lions | L | 63-0 |
| NCAAF | 2022/11/12 20:00 | Missouri Southern Lions v Washburn Ichabods Football | L | 20-37 |
| NCAAF | 2022/11/05 18:30 | NW Missouri State v Missouri Southern Lions | L | 27-5 |
| NCAAF | 2022/10/29 18:00 | Missouri Western Griffons v Missouri Southern Lions | L | 31-27 |
| NCAAF | 2022/10/22 19:00 | Missouri Southern Lions v Emporia State | L | 21-24 |
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | L | 20-17 |
| NCAAF | 2022/10/08 19:00 | Missouri Southern Lions v Blue Tigers | W | 37-14 |
| NCAAF | 2022/10/01 19:00 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 38-9 |
| NCAAF | 2022/09/25 00:00 | Fort Hays State University Tigers v Missouri Southern Lions | W | 24-25 |
| NCAAF | 2022/11/26 18:00 | Grand Valley State v NW Missouri State | L | 13-8 |
| NCAAF | 2022/11/19 19:00 | Ouachita Baptist Tigers v NW Missouri State | W | 17-47 |
| NCAAF | 2022/11/12 19:00 | Emporia State v NW Missouri State | W | 21-27 |
| NCAAF | 2022/11/05 18:30 | NW Missouri State v Missouri Southern Lions | W | 27-5 |
| NCAAF | 2022/10/29 19:00 | Nebraska Kearney v NW Missouri State | W | 24-28 |
| NCAAF | 2022/10/22 19:00 | NW Missouri State v Northeastern State Riverhawks | W | 36-3 |
| NCAAF | 2022/10/15 18:30 | NW Missouri State v Washburn Ichabods Football | W | 32-30 |
| NCAAF | 2022/10/08 19:00 | Pittsburgh State Gorillas v NW Missouri State | L | 24-22 |