[10] John Isner 4-6,4-6,4-6 Juan Martin Del Potro [6] 2018-06-04 14:40
Stadium: Court Suzanne Lenglen Round: 26 Ground: Clay
Head to Head
| ATP Miami | 2018/03/30 17:00 | Juan Martin Del Potro v John Isner | 1-6,6-7 |
| ATP Paris | 2017/11/03 13:00 | Juan Martin Del Potro v John Isner | 4-6,7-6,4-6 |
| ATP Montreal | 2017/08/07 22:30 | Juan Martin Del Potro v John Isner | 7-5,7-5 |
| ATP Stockholm | 2016/10/19 16:30 | John Isner v Juan Martin Del Potro | 4-6,6-7 |
Home History
| French Open | 2018/06/02 16:30 | John Isner v Pierre-Hugues Herbert | 7-6,6-4,7-6 |
| French Open | 2018/05/31 14:10 | John Isner v Horacio Zeballos | 6-7,7-6,7-6,6-2 |
| French Open | 2018/05/28 15:45 | John Isner v Noah Rubin | 6-3,7-6,7-6 |
| ATP Lyon | 2018/05/24 09:00 | Cameron Norrie v John Isner | 7-6,6-4 |
| ATP Lyon | 2018/05/23 11:00 | Radu Albot v John Isner | 6-7,3-6 |
| ATP Rome | 2018/05/16 09:00 | Albert Ramos-Vinolas v John Isner | 6-7,7-6,7-6 |
| ATP Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP Madrid | 2018/05/10 17:00 | John Isner v Pablo Cuevas | 6-7,7-6,7-6 |
Away History
| French Open | 2018/06/02 14:55 | Albert Ramos-Vinolas v Juan Martin Del Potro | 5-7,4-6,1-6 |
| French Open | 2018/05/31 14:55 | Julien Benneteau v Juan Martin Del Potro | 4-6,3-6,2-6 |
| French Open | 2018/05/29 15:55 | Nicolas Mahut v Juan Martin Del Potro | 6-1,1-6,2-6,4-6 |
| ATP Rome | 2018/05/16 14:35 | Juan Martin Del Potro v Stefanos Tsitsipas | 7-5,6-3 |
| ATP Madrid | 2018/05/10 13:30 | Juan Martin Del Potro v Dusan Lajovic | 6-3,4-6,6-7 |
| ATP Madrid | 2018/05/08 18:00 | Juan Martin Del Potro v Damir Dzumhur | 6-3,6-3 |
| Manolo Santana Event | 2018/05/03 18:07 | Richard Gasquet v Juan Martin Del Potro | 1-1 |
| ATP Miami | 2018/03/30 17:00 | Juan Martin Del Potro v John Isner | 1-6,6-7 |