[9] Wolverhampton 3-1 Southampton [12] 2022-01-15 15:00
Stadium: Molineux Stadium Round: 22
Referee: Michael Salisbury Home Manager: Bruno Lage Away Manager: Ralph Hasenhuttl
Head to Head
| England Premier League | 2021/09/26 13:00 | Southampton v Wolverhampton | W | 0-1 |
| England Premier League | 2021/02/14 12:00 | Southampton v Wolverhampton | W | 1-2 |
| England FA Cup | 2021/02/11 17:30 | Wolverhampton v Southampton | L | 0-2 |
| England Premier League | 2020/11/23 20:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2020/01/18 15:00 | Southampton v Wolverhampton | W | 2-3 |
| England Premier League | 2019/10/19 14:00 | Wolverhampton v Southampton | D | 1-1 |
| England Premier League | 2019/04/13 14:00 | Southampton v Wolverhampton | L | 3-1 |
| England Premier League | 2018/09/29 14:00 | Wolverhampton v Southampton | W | 2-0 |
| England EFL Cup | 2017/08/23 18:45 | Southampton v Wolverhampton | W | 0-2 |