| French Open | 05/25 16:00 | 14 | [166] Alejandro Tabilo v Matthew Ebden [229] | 4-6,6-3,6-4 | |
| Challenger Tallahassee | 04/20 14:00 | 25 | Ryan Harrison v Matthew Ebden | Cancelled | |
| Challenger Orlando | 04/13 16:20 | 25 | [138] Prajnesh Gunneswaran v Matthew Ebden [228] | 6-4,6-1 | |
| ATP Cagliari | 04/04 12:15 | 14 | [133] Cedrik-Marcel Stebe v Matthew Ebden [223] | 6-2,6-3 | |
| ATP Dubai | 03/16 13:05 | 25 | [221] Matthew Ebden v Roberto Bautista-Agut [11] | Retired | |
| ATP Marseille | 03/13 14:20 | 28 | [3] Daniil Medvedev v Matthew Ebden [287] | Retired | |
| ATP Marseille | 03/12 13:30 | 27 | [21] Karen Khachanov v Matthew Ebden [287] | 6-4,4-6,2-6 | |
| ATP Marseille | 03/10 12:30 | 26 | [287] Matthew Ebden v Emil Ruusuvuori [87] | 6-2,6-2 | |
| ATP Marseille | 03/09 12:30 | 25 | [287] Matthew Ebden v Benjamin Bonzi [127] | 3-6,7-6,6-3 | |
| ATP Marseille | 03/08 12:15 | 19 | [212] Mathias Bourgue v Matthew Ebden [287] | 4-6,3-6 | |
| ATP Marseille | 03/07 15:20 | 14 | [285] Matthew Ebden v Frederico Ferreira Silva [179] | 6-7,6-4,7-6 | |
| Challenger St. Petersburg | 03/04 10:45 | 26 | [285] Matthew Ebden v Lucas Catarina [432] | 6-7,2-6 | |
| Challenger St. Petersburg | 03/03 07:00 | 25 | [285] Matthew Ebden v Pedja Krstin [276] | 6-1,6-4 | |
| ATP Singapore | 02/26 06:00 | 27 | [114] Alexei Popyrin v Matthew Ebden [316] | 6-4,7-6 | |
| ATP Singapore | 02/25 09:00 | 26 | [316] Matthew Ebden v John Millman [39] | 6-4,6-1 | |
| ATP Singapore | 02/24 06:25 | 25 | Yuki Bhambri v Matthew Ebden | 3-6,6-7 | |
| ATP Great Ocean Road Open | 02/03 05:05 | 25 | [320] Matthew Ebden v Thiago Monteiro [83] | 7-6,4-6,3-6 | |
| ATP Great Ocean Road Open | 02/02 05:05 | 24 | [320] Matthew Ebden v Federico Delbonis [77] | 6-3,7-6 | |
| Australian Open | 01/10 14:45 | 60 | [317] Matthew Ebden v Jason Kubler [259] | 5-7,6-2,4-6 | |
| Challenger Bengaluru | 02/12 06:45 | 25 | [130] Mohamed Safwat v Matthew Ebden [293] | 7-6,6-7,7-5 | |
| Challenger Bengaluru | 02/10 13:00 | 24 | [293] Matthew Ebden v Tsung-Hua Yang [317] | 6-0,4-6,7-6 | |
| ATP Pune | 02/02 09:30 | 164 | [240] Matthew Ebden v Lukas Rosol [177] | 2-6,5-7 | |
| ATP Pune | 02/01 09:30 | 64 | [137] Zhizhen Zhang v Matthew Ebden [240] | 3-6,2-6 | |
| Australian Open | 01/14 00:00 | 44 | [115] Gianluca Mager v Matthew Ebden [237] | 7-5,6-4 | |
| Challenger Canberra | 01/06 05:05 | 24 | [236] Matthew Ebden v Mitchell Krueger [165] | 2-6,4-6 | |
| Challenger Jinan | 09/04 04:25 | 25 | [282] Frederico Ferreira Silva v Matthew Ebden [110] | 6-4,6-4 | |
| ATP Washington | 07/30 00:35 | 24 | [116] Matthew Ebden v Tim Smyczek [281] | 4-6,4-6 | |
| ATP Atlanta | 07/25 18:00 | 26 | [100] Matthew Ebden v Bernard Tomic [106] | 4-6,6-7 | |
| ATP Atlanta | 07/23 16:30 | 25 | [100] Matthew Ebden v Kamil Majchrzak [102] | 7-6,6-3 | |
| ATP Newport | 07/19 18:35 | 27 | [15] John Isner v Matthew Ebden [110] | 4-6,6-3,6-4 |