| ATP Istanbul | 05/02 14:00 | 26 | [186] Marco Trungelliti v Paolo Lorenzi [76] | 2-6,6-7 | |
| ATP Istanbul | 04/30 14:00 | 25 | [251] Cem Ilkel v Paolo Lorenzi [76] | 2-6,3-6 | |
| ATP Budapest | 04/24 12:00 | 25 | [79] Nikoloz Basilashvili v Paolo Lorenzi [66] | 6-4,6-2 | |
| ATP Monte Carlo | 04/16 14:30 | 24 | [82] Pierre-Hugues Herbert v Paolo Lorenzi [63] | 7-6,6-4 | |
| ATP Monte Carlo | 04/16 09:00 | - | [27] Filip Krajinovic v Paolo Lorenzi [57] | Cancelled | |
| ATP Marrakech | 04/10 14:00 | 25 | [55] Mischa Zverev v Paolo Lorenzi [57] | 6-3,6-4 | |
| Challenger San Luis Potosi | 03/29 01:10 | 25 | [57] Paolo Lorenzi v Austin Krajicek [295] | 7-6,1-6,3-6 | |
| ATP Dubai | 02/26 06:00 | 25 | Robin Haase v Paolo Lorenzi | Cancelled | |
| ATP Quito | 02/08 17:00 | 26 | Paolo Lorenzi v Roberto C Baena | 6-7,5-7 | |
| Australian Open | 01/15 04:15 | 23 | Paolo Lorenzi v Damir Dzumhur | 6-3,6-2,6-7,2-6,4-6 | |
| ATP Sydney | 01/11 03:40 | 27 | Paolo Lorenzi v Daniil Medvedev | 3-6,3-6 | |
| ATP Sydney | 01/10 02:00 | 26 | Alberto Ramos-Vinolas v Paolo Lorenzi | 3-6,5-7 | |
| ATP Sydney | 01/07 02:35 | 25 | Paolo Lorenzi v Jordan Thompson | 7-6,6-4 | |
| ATP Doha | 01/02 19:15 | 25 | Paolo Lorenzi v Gael Monfils | 3-6,6-3,4-6 | |
| ATP Paris | 10/31 11:00 | 24 | [58] Joao Sousa v Paolo Lorenzi [41] | 6-4,7-5 | |
| ATP Paris | 10/30 10:00 | 24 | Gael Monfils v Paolo Lorenzi | Cancelled | |
| ATP Basel | 10/23 18:15 | 25 | [57] Hyeon Chung v Paolo Lorenzi [41] | 6-3,6-1 | |
| ATP Moscow | 10/17 13:00 | 25 | [90] Laslo Djere v Paolo Lorenzi [40] | 4-6,7-6,6-4 | |
| ATP Shanghai | 10/10 05:00 | 24 | [48] Aljaz Bedene v Paolo Lorenzi [39] | 6-1,6-4 | |
| ATP Beijing | 10/03 05:50 | 25 | [54] Leonardo Mayer v Paolo Lorenzi [38] | 7-6,5-7,6-4 | |
| ATP Shenzhen | 09/27 08:30 | 26 | [495] Zhizhen Zhang v Paolo Lorenzi [39] | 4-6,6-3,7-6 | |
| ATP St Petersburg | 09/18 12:20 | 25 | [38] Paolo Lorenzi v Damir Dzumhur [55] | 5-7,5-7 | |
| US Open | 09/03 21:10 | 26 | [40] Paolo Lorenzi v Kevin Anderson [32] | 4-6,3-6,7-6,4-6 | |
| US Open | 09/01 15:00 | 25 | [82] Thomas Fabbiano v Paolo Lorenzi [40] | 2-6,4-6,4-6 | |
| US Open | 08/30 20:50 | 24 | [40] Paolo Lorenzi v Gilles Muller [23] | 6-7,6-3,7-6,6-3 | |
| US Open | 08/28 18:15 | 23 | [50] Joao Sousa v Paolo Lorenzi [40] | 6-4,3-6,6-7,2-6 | |
| ATP Winston-Salem | 08/23 20:35 | 26 | [116] Taylor Fritz v Paolo Lorenzi [40] | 7-6,7-6 | |
| ATP Winston-Salem | 08/22 21:25 | 25 | [114] Thiago Monteiro v Paolo Lorenzi [40] | 6-2,4-6,4-6 | |
| ATP Cincinnati | 08/15 19:45 | 24 | Pablo Carreno-Busta v Paolo Lorenzi | 6-3,6-3 | |
| ATP Montreal | 08/09 21:25 | 25 | [38] Paolo Lorenzi v Nick Kyrgios [24] | 2-6,3-6 |