| WTA Shenzhen | 01/06 03:00 | 25 | [36] Elena Rybakina v Saisai Zheng [40] | 6-2,1-6,6-2 | |
| WTA Zhuhai | 10/26 07:00 | 28 | [10] Kiki Bertens v Saisai Zheng [40] | 2-6,6-3,6-4 | |
| WTA Zhuhai | 10/25 09:40 | 3 | [15] Petra Martic v Saisai Zheng [40] | 6-4,6-3 | |
| WTA Zhuhai | 10/22 11:30 | 1 | [13] Madison Keys v Saisai Zheng [40] | 4-6,2-6 | |
| WTA Tianjin | 10/10 04:35 | 26 | [38] Saisai Zheng v Veronika Kudermetova [45] | Retired | |
| WTA Tianjin | 10/08 06:35 | 25 | [38] Saisai Zheng v Yingying Duan [363] | 7-6,6-2 | |
| WTA Beijing | 10/02 10:00 | 26 | [1] Ashleigh Barty v Saisai Zheng [39] | 6-3,6-7,6-2 | |
| WTA Beijing | 10/01 09:05 | 25 | [39] Saisai Zheng v Sloane Stephens [12] | 6-3,6-1 | |
| WTA Beijing | 09/28 04:30 | 24 | [40] Saisai Zheng v Monica Puig [71] | 4-6,6-3,7-6 | |
| WTA Guangzhou | 09/18 07:35 | 26 | [126] Jasmine Paolini v Saisai Zheng [37] | 7-5,3-6,7-5 | |
| WTA Guangzhou | 09/17 06:00 | 25 | [329] Yingying Duan v Saisai Zheng [37] | 7-6,6-7,1-6 | |
| WTA Zhengzhou | 09/13 08:30 | 27 | [46] Ajla Tomljanovic v Saisai Zheng [38] | 6-1,6-7,6-4 | |
| WTA Zhengzhou | 09/13 04:00 | 26 | [38] Saisai Zheng v Alison Riske [34] | 7-5,6-3 | |
| WTA Zhengzhou | 09/10 07:10 | 25 | [155] Bibiane Schoofs v Saisai Zheng [38] | 6-7,1-6 | |
| US Open Women | 08/26 18:50 | 23 | [38] Saisai Zheng v Venus Williams [52] | 1-6,0-6 | |
| WTA New York | 08/19 14:00 | 25 | Saisai Zheng v Viktoria Kuzmova | Cancelled | |
| WTA Cincinnati | 08/14 15:00 | 25 | [9] Aryna Sabalenka v Saisai Zheng [39] | 6-4,6-3 | |
| WTA Cincinnati | 08/13 15:00 | 24 | [49] Viktoria Kuzmova v Saisai Zheng [39] | 3-6,1-6 | |
| WTA Toronto | 08/06 17:25 | 24 | [38] Saisai Zheng v Tatjana Maria [74] | 3-6,4-6 | |
| WTA San Jose | 08/04 23:00 | 29 | [55] Saisai Zheng v Aryna Sabalenka [10] | 6-3,7-6 | |
| WTA San Jose | 08/03 21:00 | 28 | [30] Maria Sakkari v Saisai Zheng [55] | 6-7,2-6 | |
| WTA San Jose | 08/03 02:00 | 27 | [23] Amanda Anisimova v Saisai Zheng [55] | 7-5,5-7,4-6 | |
| WTA San Jose | 08/01 18:00 | 26 | [55] Saisai Zheng v Danielle Collins [33] | 6-2,6-0 | |
| WTA San Jose | 07/30 19:30 | 25 | [107] Heather Watson v Saisai Zheng [55] | 3-6,1-6 | |
| Wimbledon Women | 07/02 12:00 | 23 | [1] Ashleigh Barty v Saisai Zheng [43] | 6-4,6-2 | |
| WTA Eastbourne | 06/24 10:00 | 24 | [16] Marketa Vondrousova v Saisai Zheng [43] | 6-2,6-3 | |
| WTA Mallorca | 06/18 09:00 | 25 | [44] Saisai Zheng v Samantha Stosur [115] | 4-6,5-7 | |
| WTA Hertogenbosch | 06/11 09:00 | 25 | Yafan Wang v Saisai Zheng | Cancelled | |
| French Open Women | 05/28 14:40 | 23 | [45] Saisai Zheng v Qiang Wang [16] | 1-6,5-7 | |
| WTA Strasbourg | 05/22 10:15 | 26 | [264] Marta Kostyuk v Saisai Zheng [45] | 6-3,6-1 |