| WTA Strasbourg | 05/19 16:05 | 25 | [259] Harmony Tan v Saisai Zheng [46] | 6-7,6-7 | |
| WTA Rome | 05/13 10:45 | 24 | [46] Saisai Zheng v Garbine Muguruza [19] | 3-6,4-6 | |
| WTA Madrid | 05/08 15:20 | 26 | [8] Sloane Stephens v Saisai Zheng [49] | 3-6,6-3,6-2 | |
| WTA Madrid | 05/07 14:55 | 25 | [49] Saisai Zheng v Alize Cornet [54] | 6-2,3-6,6-4 | |
| WTA Madrid | 05/05 09:00 | 24 | [56] Yafan Wang v Saisai Zheng [46] | 5-7,6-7 | |
| WTA Anning | 04/28 09:00 | 29 | [42] Shuai Zhang v Saisai Zheng [49] | 4-6,1-6 | |
| WTA Anning | 04/27 06:00 | 28 | [281] Kaylah McPhee v Saisai Zheng [49] | 6-3,0-6,1-6 | |
| WTA Anning | 04/26 04:00 | 27 | [235] Alexandra Cadantu v Saisai Zheng [49] | 1-6,4-6 | |
| WTA Anning | 04/24 04:45 | 26 | [241] Jana Cepelova v Saisai Zheng [49] | 2-6,1-6 | |
| WTA Anning | 04/22 03:45 | 25 | [287] Peangtarn Plipuech v Saisai Zheng [43] | 6-7,1-6 | |
| WTA Miami | 03/20 18:25 | 23 | [39] Saisai Zheng v Katerina Siniakova [42] | 3-6,1-6 | |
| WTA Indian Wells | 03/07 19:00 | 23 | [65] Kristina Mladenovic v Saisai Zheng [39] | 7-5,6-2 | |
| WTA Acapulco | 03/01 04:30 | 27 | [40] Saisai Zheng v Bianca Andreescu [71] | 6-7,1-6 | |
| WTA Acapulco | 02/27 22:00 | 26 | [40] Saisai Zheng v Timea Babos [110] | 4-6,6-4,6-3 | |
| WTA Acapulco | 02/27 01:20 | 25 | [40] Saisai Zheng v Renata Zarazua [242] | 3-6,7-5,6-4 | |
| WTA Dubai | 02/19 10:25 | 25 | [19] Garbine Muguruza v Saisai Zheng [41] | 7-5,6-2 | |
| WTA Dubai | 02/17 09:30 | 24 | [41] Ajla Tomljanovic v Saisai Zheng [42] | 2-6,6-4,5-7 | |
| 2019 Fed Cup | 02/09 05:00 | 29 | [42] Saisai Zheng v Zarina Diyas [96] | 3-6,2-6 | |
| 2019 Fed Cup | 02/08 06:20 | - | Saisai Zheng v Beatrice Gumulya | 3-6,6-3,6-1 | |
| 2019 Fed Cup | 02/07 05:00 | - | [42] Saisai Zheng v Su Jeong Jang [286] | 3-6,6-3,6-3 | |
| WTA Hua Hin | 02/01 07:00 | 27 | [49] Ajla Tomljanovic v Saisai Zheng [42] | 6-1,6-3 | |
| WTA Hua Hin | 01/30 09:25 | 26 | [71] Irina-Camelia Begu v Saisai Zheng [42] | 2-6,4-6 | |
| WTA Hua Hin | 01/29 08:00 | 25 | [101] Mandy Minella v Saisai Zheng [42] | 7-6,4-6,4-6 | |
| Australian Open Women | 01/15 03:05 | 23 | [40] Saisai Zheng v Garbine Muguruza [18] | 2-6,3-6 | |
| WTA Shenzhen | 12/30 08:15 | 25 | [39] Saisai Zheng v Pauline Parmentier [56] | 2-6,6-3,2-6 | |
| WTA Taipei | 11/14 03:00 | 25 | [41] Saisai Zheng v Valentini Gram'lou [160] | Cancelled | |
| ITF Women Shenzhen | 11/11 02:30 | 29 | [46] Saisai Zheng v Ivana Jorovic [185] | 3-6,6-2,4-6 | |
| ITF Women Shenzhen | 11/10 03:00 | 28 | [46] Saisai Zheng v Misaki Doi [139] | 6-4,6-1 | |
| ITF Women Shenzhen | 11/09 04:05 | 27 | [46] Saisai Zheng v Valentini Grammatikopoulou [165] | 6-2,6-1 | |
| ITF Women Shenzhen | 11/08 04:00 | 26 | [46] Saisai Zheng v Ankita Raina [192] | 6-3,6-1 |