| ITF W25 Istanbul | 10/28 07:00 | 26 | [277] Despina Papamichail v Katarina Zavatska [116] | 2-6,5-7 | |
| ITF W25 Istanbul | 10/27 08:50 | 25 | Despina Papamichail v Doga Akyurek | 6-3,6-2 | |
| ITF W25 Istanbul | 10/26 07:00 | 54 | [277] Despina Papamichail v Ekaterina Kazionova [423] | 6-3,3-6,10-4 | |
| ITF W25 Istanbul | 10/25 07:00 | 54 | Despina Papamichail v Betina Tokac | 6-1,6-1 | |
| ITF W25 Reims | 10/18 10:15 | 54 | [278] Despina Papamichail v Francesca Jones [258] | 6-7,6-4,5-10 | |
| ITF W25 Cherbourg | 10/11 15:40 | 54 | Lucie Wargnier v Despina Papamichail | 6-4,2-6,11-9 | |
| ITF W25 Olimpia | 03/10 19:00 | 25 | [320] Francesca Jones v Despina Papamichail [264] | 6-2,6-1 | |
| ITF W25 Antalya | 03/06 07:00 | 27 | [263] Despina Papamichail v Amina Anshba [352] | 3-6,1-6 | |
| ITF W25 Antalya | 03/05 06:50 | 26 | [263] Despina Papamichail v Tena Lukas [262] | 2-6,6-2,6-3 | |
| ITF W25 Antalya | 03/04 07:00 | 25 | Despina Papamichail v Ipek Oz | 7-6,6-2 | |
| ITF W60 Cairo | 02/17 11:25 | 54 | [260] Despina Papamichail v Yidi Yang [461] | 3-6,6-2,8-10 | |
| ITF W60 Cairo | 02/16 08:55 | 54 | Despina Papamichail v Merna Refaat | 6-0,6-2 | |
| ITF W25 Trnava | 02/12 16:40 | 25 | [259] Despina Papamichail v Anna Kubareva [479] | 2-6,4-6 | |
| 2020 Fed Cup | 02/08 12:05 | - | [143] Viktoriya Tomova v Despina Papamichail [258] | 6-2,6-4 | |
| 2020 Fed Cup | 02/06 15:25 | 2 | [221] Julia Grabher v Despina Papamichail [258] | 1-6,6-4,7-5 | |
| 2020 Fed Cup | 02/05 16:30 | 1 | [22] Anett Kontaveit v Despina Papamichail [258] | 3-6,6-3,6-0 | |
| ITF W25 Pune | 12/10 07:00 | 25 | [471] Shalimar Talbi v Despina Papamichail [267] | 6-4,3-6,6-1 | |
| ITF W25 Solapur | 12/04 10:15 | 25 | Despina Papamichail v Emma Raducanu | 2-6,1-6 | |
| ITF W25 Solarino | 11/27 09:00 | 25 | [286] Lara Salden v Despina Papamichail [263] | 3-6,6-4,6-1 | |
| ITF W25 Naples | 11/20 14:00 | 25 | [311] Gabriela Talaba v Despina Papamichail [263] | 6-3,6-7,6-2 | |
| ITF W25 Orlando | 11/13 15:00 | 25 | Despina Papamichail v Maria Mateas | 3-6,6-7 | |
| ITF W60 Colina | 11/05 18:20 | 25 | [407] Carolina Meligeni Rodrigues Alves v Despina Papamichail [260] | 4-6,7-5,6-3 | |
| ITF W60 Asuncion | 10/30 19:25 | 25 | Barbara Gatica v Despina Papamichail | 6-3,6-1 | |
| ITF W100 Szekesfehervar | 10/22 08:55 | 54 | [263] Despina Papamichail v Marie Benoit [306] | 6-2,3-6,5-10 | |
| ITF W100 Szekesfehervar | 10/21 13:55 | 54 | [263] Despina Papamichail v Vivien Juhaszova [325] | 5-7,6-3,10-8 | |
| WTA Luxembourg | 10/12 16:20 | 45 | [261] Despina Papamichail v Marta Kostyuk [163] | 4-6,3-6 | |
| ITF W25 Santa Margherita | 10/08 12:05 | 25 | Corinna Dentoni v Despina Papamichail | 3-6,6-0,6-0 | |
| ITF W60 Valencia | 09/24 09:00 | 54 | [263] Despina Papamichail v Guiomar MZD Reales [349] | 6-3,2-6,8-10 | |
| ITF W60 Valencia | 09/23 10:30 | 54 | Despina Papamichail v Jessica B Maneiro | 6-4,6-3 | |
| ITF W25 Frydek Mistek | 09/14 09:00 | 28 | Despina Papamichail v Ekaterine Gorgodze | 0-6,2-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.