| ITF W75 Chiasso | 04/17 12:30 | 25 | [235] Despina Papamichail v Maria Sara Popa [432] | 7-5,5-7,6-7 | |
| Billie Jean King Cup | 04/09 10:00 | 1 | [111] Aleksandra Krunic v Despina Papamichail [235] | 6-0,6-3 | |
| Billie Jean King Cup | 04/08 09:50 | 1 | [469] Kajsa Rinaldo Persson v Despina Papamichail [235] | 4-6,4-6 | |
| ITF W35 Santa Margherita | 04/03 07:25 | 25 | [245] Despina Papamichail v Diletta Cherubini [412] | 2-6,7-6,4-6 | |
| ITF W35 Terrassa | 03/29 09:30 | 28 | [260] Despina Papamichail v Lois Boisson [293] | 3-6,6-0,1-6 | |
| ITF W35 Terrassa | 03/28 09:00 | 27 | [467] Caijsa W Hennemann v Despina Papamichail [260] | 1-6,6-3,4-6 | |
| ITF W35 Terrassa | 03/27 08:55 | 26 | [385] Ilona G Ghioroaie v Despina Papamichail [260] | 4-6,5-7 | |
| ITF W35 Terrassa | 03/26 14:35 | 25 | Sara Dols v Despina Papamichail | 2-6,3-6 | |
| ITF W35 Alaminos-Larnaca | 03/24 09:00 | 29 | [293] Lois Boisson v Despina Papamichail [260] | 6-2,6-0 | |
| ITF W35 Alaminos-Larnaca | 03/23 08:00 | 28 | [260] Despina Papamichail v Deborah Chiesa [460] | 4-6,6-3,6-3 | |
| ITF W35 Alaminos-Larnaca | 03/22 08:00 | 27 | [214] Andreea Mitu v Despina Papamichail [260] | 2-6,0-6 | |
| ITF W35 Alaminos-Larnaca | 03/21 07:30 | 26 | [260] Despina Papamichail v Tena Lukas [203] | 4-6,6-2,6-1 | |
| ITF W35 Alaminos-Larnaca | 03/20 09:50 | 25 | [370] Julia Middendorf v Despina Papamichail [260] | 1-6,3-6 | |
| ITF W35 Alaminos-Larnaca | 03/12 12:05 | 25 | [181] Noma Noha Akugue v Despina Papamichail [267] | 7-5,3-6,6-1 | |
| WTA San Diego | 02/24 23:20 | 14 | [118] Mai Hontama v Despina Papamichail [254] | 6-3,6-4 | |
| ITF W50 Mexico City | 02/20 19:40 | 25 | [254] Despina Papamichail v Victoria Hu [329] | 1-6,7-5,4-6 | |
| ITF W50 Morelia | 02/14 16:55 | 26 | [146] Rebecca Marino v Despina Papamichail [250] | 6-2,6-3 | |
| ITF W50 Morelia | 02/13 17:00 | 25 | [250] Despina Papamichail v Elvina Kalieva [226] | 7-5,4-6,6-4 | |
| WTA Abu Dhabi | 02/03 08:25 | 14 | [229] Despina Papamichail v Danielle Collins [69] | 2-6,3-6 | |
| Australian Open Women | 01/10 01:35 | 14 | [177] Raluka Serban v Despina Papamichail [219] | 7-5,6-2 | |
| WTA Montevideo | 12/07 21:45 | 26 | [94] Diane Parry v Despina Papamichail [221] | 6-1,6-2 | |
| WTA Montevideo | 12/05 16:40 | 25 | [221] Despina Papamichail v Victoria Hu [332] | 6-4,6-2 | |
| WTA Buenos Aires | 11/27 15:25 | 25 | [222] Despina Papamichail v Jamie Loeb [302] | 3-6,2-6 | |
| WTA Florianopolis | 11/22 15:00 | 26 | [224] Despina Papamichail v Renata Zarazua [151] | 4-6,2-6 | |
| WTA Florianopolis | 11/20 15:00 | 25 | [156] Julia Riera v Despina Papamichail [224] | 4-6,6-7 | |
| WTA Colina | 11/15 16:20 | 26 | [131] Leolia Jeanjean v Despina Papamichail [228] | 2-6,6-4,6-2 | |
| WTA Colina | 11/13 18:15 | 25 | [212] Solana Sierra v Despina Papamichail [228] | 3-6,2-6 | |
| ITF W100 Les Franqueses | 10/25 11:20 | 25 | Nahia Berecoechea v Despina Papamichail | 1-6,6-2,6-2 | |
| WTA Monastir | 10/14 10:00 | 14 | [169] Katarina Zavatska v Despina Papamichail [207] | 3-6,6-2,6-4 | |
| WTA Tokyo | 09/28 04:25 | 26 | [13] Daria Kasatkina v Despina Papamichail [220] | 6-4,6-4 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.