| WTA Monastir | 10/14 10:00 | 14 | [169] Katarina Zavatska v Despina Papamichail [207] | 3-6,6-2,6-4 | |
| WTA Tokyo | 09/28 04:25 | 26 | [13] Daria Kasatkina v Despina Papamichail [220] | 6-4,6-4 | |
| WTA Tokyo | 09/26 05:35 | 25 | [256] Sakura Hosogi v Despina Papamichail [220] | 6-7,5-7 | |
| WTA Tokyo | 09/26 04:50 | 25 | Natsumi Kawaguchi v Despina Papamichail | Cancelled | |
| WTA Tokyo | 09/24 03:30 | 19 | [190] Despina Papamichail v Ellen Perez [431] | 6-4,6-3 | |
| WTA Tokyo | 09/23 06:55 | 14 | [190] Despina Papamichail v Lidziya Marozava [61] | 6-1,6-1 | |
| WTA Guangzhou | 09/19 06:00 | 25 | [190] Despina Papamichail v Zhuoxuan Bai [129] | 3-6,5-7 | |
| WTA Guangzhou | 09/17 06:00 | 19 | [282] Yexin Ma v Despina Papamichail [190] | 3-6,3-6 | |
| WTA Guangzhou | 09/16 06:20 | 14 | [93] Maia Lumsden v Despina Papamichail [190] | 6-7,1-6 | |
| WTA Osaka | 09/10 02:55 | 19 | [191] Despina Papamichail v Arianne Hartono [206] | 1-6,5-7 | |
| WTA Osaka | 09/09 04:25 | 14 | [191] Despina Papamichail v Naiktha Bains [295] | 6-4,6-7,6-0 | |
| US Open Women | 08/25 18:40 | 15 | [193] Despina Papamichail v Vera Zvonareva [38] | 5-7,5-7 | |
| US Open Women | 08/23 20:20 | 14 | [89] Jule Niemeier v Despina Papamichail [193] | 3-6,4-6 | |
| WTA Barranquilla | 08/15 18:30 | 25 | [144] Leolia Jeanjean v Despina Papamichail [193] | 6-4,6-3 | |
| ITF W80 Brasilia | 08/11 15:35 | 27 | [202] Despina Papamichail v Laura Pigossi [144] | 2-6,4-6 | |
| ITF W80 Brasilia | 08/10 13:00 | 26 | [202] Despina Papamichail v Ana Candiotto [447] | 6-4,6-3 | |
| ITF W80 Brasilia | 08/08 14:55 | 25 | Despina Papamichail v Miriana Tona | 6-3,5-7,7-5 | |
| ITF W60 Barcelona | 08/04 17:30 | 27 | [193] Valeria Savinykh v Despina Papamichail [213] | 3-6,7-6,6-1 | |
| ITF W60 Barcelona | 08/03 20:00 | 26 | Emilie Lindh v Despina Papamichail | 3-6,6-3,4-6 | |
| ITF W60 Barcelona | 08/02 17:30 | 25 | Nahia Berecoechea v Despina Papamichail | 3-6,3-6 | |
| WTA Hamburg | 07/23 13:30 | 19 | [169] Kaja Juvan v Despina Papamichail [201] | 6-1,6-2 | |
| WTA Hamburg | 07/22 15:00 | 14 | [293] Katharina Hobgarski v Despina Papamichail [201] | 4-6,3-6 | |
| WTA Iasi | 07/17 14:45 | 25 | [472] Anca Alexia Todoni v Despina Papamichail [201] | 6-4,6-4 | |
| WTA Contrexeville | 07/10 11:40 | 25 | [188] Despina Papamichail v Anna-Lena Friedsam [87] | 3-6,4-6 | |
| Wimbledon Women | 06/29 14:40 | 19 | [188] Despina Papamichail v Viktorija Golubic [138] | 2-6,6-7 | |
| Wimbledon Women | 06/28 14:45 | 15 | [112] Oceane Dodin v Despina Papamichail [188] | 6-7,6-7 | |
| Wimbledon Women | 06/27 12:50 | 14 | [207] Zeynep Sonmez v Despina Papamichail [188] | 3-6,6-3,4-6 | |
| ITF W40 Ystad | 06/21 11:50 | 25 | [437] Julia Middendorf v Despina Papamichail [189] | 7-5,4-6,7-6 | |
| ITF W60 Ricany | 06/15 08:00 | 26 | [175] Despina Papamichail v Seone Mendez [369] | 2-6,7-5,3-6 | |
| ITF W60 Ricany | 06/14 09:40 | 25 | [175] Despina Papamichail v Amina Anshba [389] | 6-2,6-3 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.