| ITF W25 Saint Palais Sur Mer | 09/11 12:55 | 28 | [230] Despina Papamichail v Amandine Hesse [229] | 4-6,5-7 | |
| ITF W25 Saint Palais Sur Mer | 09/10 12:30 | 27 | [397] Leolia Jeanjean v Despina Papamichail [230] | 1-6,4-6 | |
| ITF W25 Saint Palais Sur Mer | 09/09 13:25 | 26 | Laia Petretic v Despina Papamichail | 4-6,2-6 | |
| ITF W25 Saint Palais Sur Mer | 09/07 11:00 | 25 | [444] Magali Kempen v Despina Papamichail [230] | 3-6,2-6 | |
| US Open Women | 08/26 16:35 | 15 | [229] Despina Papamichail v Dalma Galfi [152] | 6-7,1-6 | |
| US Open Women | 08/24 22:20 | 14 | [120] Renata Zarazua v Despina Papamichail [229] | 5-7,6-7 | |
| ITF W60 San Bartolome De Tirajana | 08/11 08:30 | 25 | [226] Despina Papamichail v Barbara Gatica [349] | 3-6,6-7 | |
| ITF W60 Grodzisk Mazowiecki | 07/30 09:00 | 27 | [185] Ekaterine Gorgodze v Despina Papamichail [227] | 6-3,6-0 | |
| ITF W60 Grodzisk Mazowiecki | 07/29 10:05 | 26 | [371] Martyna Kubka v Despina Papamichail [227] | 3-6,4-6 | |
| ITF W60 Grodzisk Mazowiecki | 07/28 10:00 | 25 | Andrea Gamiz v Despina Papamichail | 6-3,3-6,6-7 | |
| WTA Palermo | 07/18 17:45 | 19 | [199] Despina Papamichail v Katharina Gerlach [225] | 4-6,6-2,5-7 | |
| WTA Palermo | 07/17 19:25 | 14 | [199] Despina Papamichail v Dalila Spiteri [499] | 3-6,7-5,6-2 | |
| ITF W60 Amstelveen | 07/09 10:00 | 27 | [282] Alexandra Cadantu v Despina Papamichail [227] | 3-6,6-3,6-4 | |
| ITF W60 Amstelveen | 07/08 12:10 | 26 | [478] Andreea Prisacariu v Despina Papamichail [227] | 4-6,4-6 | |
| ITF W60 Amstelveen | 07/07 09:55 | 25 | [255] Chloe Paquet v Despina Papamichail [227] | 6-2,4-6,3-6 | |
| ITF W25 Wroclaw | 07/01 13:10 | 26 | [437] Weronika Falkowska v Despina Papamichail [227] | 4-6,6-3,6-4 | |
| ITF W25 Wroclaw | 06/30 09:30 | 25 | Nikola Tomanova v Despina Papamichail | 3-6,3-6 | |
| ITF W60 Charleston | 06/27 14:55 | 29 | [240] Gabriela Ce v Despina Papamichail [227] | 6-1,3-6,3-6 | |
| ITF W60 Charleston | 06/26 13:55 | 28 | [372] Fernanda Contreras Gomez v Despina Papamichail [261] | 2-6,2-6 | |
| ITF W60 Charleston | 06/25 13:55 | 27 | [300] Alexa Glatch v Despina Papamichail [261] | 6-4,0-6,4-6 | |
| ITF W60 Charleston | 06/24 16:40 | 26 | Charlotte Chavatipon v Despina Papamichail | 3-6,3-6 | |
| ITF W60 Charleston | 06/23 13:30 | 25 | [368] Aldila Sutjiadi v Despina Papamichail [261] | 6-2,3-6,1-6 | |
| ITF W25 Jonkoping | 06/14 12:25 | 25 | [395] Camilla Rosatello v Despina Papamichail [258] | 7-5,6-3 | |
| ITF W25 Grado | 06/02 17:45 | 26 | [106] Liudmila Samsonova v Despina Papamichail [269] | 6-0,6-4 | |
| ITF W25 Grado | 06/01 10:25 | 25 | Melania Delai v Despina Papamichail | 6-7,5-7 | |
| WTA Strasbourg | 05/23 12:15 | 19 | Despina Papamichail v Maryna Zanevska | 6-4,2-6,5-7 | |
| WTA Strasbourg | 05/22 12:00 | 14 | Angelina Gabueva v Despina Papamichail | 5-7,2-6 | |
| WTA Strasbourg | 05/22 11:45 | 14 | Zarina Diyas v Despina Papamichail | Cancelled | |
| WTA Strasbourg | 05/22 10:30 | - | [471] Angelina Gabueva v Despina Papamichail [273] | 5-7,2-5 | |
| ITF W25 Platja D’Aro | 05/20 14:00 | 26 | Despina Papamichail v Carlota M Cirez | 4-6,2-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.