| WTA Warsaw | 07/24 15:30 | - | [178] Raluka Serban v Despina Papamichail [171] | 4-6,7-6,6-1 | |
| WTA Warsaw | 07/23 10:50 | 45 | Weronika Ewald v Despina Papamichail | Retired | |
| WTA Palermo | 07/17 16:35 | - | [226] Marina B Ribera v Despina Papamichail [195] | 6-2,6-1 | |
| WTA Palermo | 07/16 20:00 | 26 | [195] Despina Papamichail v Anastasia Zakharova [161] | 6-4,6-4 | |
| WTA Budapest | 07/13 15:10 | 26 | [53] Anna Bondar v Despina Papamichail [195] | 6-2,6-3 | |
| WTA Budapest | 07/12 12:55 | 25 | [195] Despina Papamichail v Dalma Galfi [81] | 7-6,6-3 | |
| WTA Budapest | 07/10 09:00 | 19 | Varvara Flink v Despina Papamichail | 6-7,3-6 | |
| WTA Budapest | 07/09 10:25 | 14 | [375] Amarissa K Toth v Despina Papamichail [196] | Retired | |
| ITF W100 Charleston | 06/30 19:40 | 26 | [362] Victoria Duval v Despina Papamichail [196] | 7-5,6-1 | |
| ITF W100 Charleston | 06/29 13:00 | 25 | [331] Ellie Douglas v Despina Papamichail [196] | 7-6,3-6,4-6 | |
| Wimbledon Women | 06/22 15:35 | 15 | [255] Natalija Stevanovic v Despina Papamichail [147] | 6-2,6-4 | |
| Wimbledon Women | 06/21 14:05 | 14 | [224] Eva Lys v Despina Papamichail [147] | 6-3,3-6,2-6 | |
| ITF W60 Ceska Lipa | 06/18 09:25 | 28 | [249] Jesika Maleckova v Despina Papamichail [156] | 6-3,6-1 | |
| ITF W60 Ceska Lipa | 06/17 08:00 | 27 | [156] Despina Papamichail v Conny Perrin [302] | 7-6,6-3 | |
| ITF W60 Ceska Lipa | 06/16 08:00 | 26 | [156] Despina Papamichail v Tereza Smitkova [279] | 6-2,6-0 | |
| ITF W60 Ceska Lipa | 06/15 09:40 | 25 | [156] Despina Papamichail v Barbora Palicova [435] | 4-6,6-1,6-1 | |
| ITF W60 Caserta | 06/08 08:00 | 25 | [163] Despina Papamichail v Cristiana Ferrando [253] | 6-1,6-7,6-7 | |
| ITF W60 Brescia | 06/05 13:30 | 29 | Angela Fita Boluda v Despina Papamichail | 6-2,6-0 | |
| ITF W60 Brescia | 06/04 12:30 | 28 | [226] Anna-Lena Friedsam v Despina Papamichail [170] | 4-6,6-3,6-7 | |
| ITF W60 Brescia | 06/03 09:30 | 27 | [170] Despina Papamichail v Jazmin Ortenzi [463] | 5-7,6-3,6-2 | |
| ITF W60 Brescia | 06/02 08:00 | 26 | [170] Despina Papamichail v Katarina Zavatska [221] | 0-6,7-5,6-4 | |
| ITF W60 Brescia | 06/01 10:00 | 25 | [170] Despina Papamichail v Malene Helgo [320] | 6-2,3-6,6-1 | |
| French Open Women | 05/17 08:00 | 14 | [172] Despina Papamichail v Ysaline Bonaventure [170] | 1-6,6-3,6-7 | |
| ITF W100 La Bisbal | 05/12 13:45 | 26 | [173] Despina Papamichail v Marina B Ribera [318] | 6-4,5-7,3-6 | |
| ITF W100 La Bisbal | 05/11 13:20 | 25 | [173] Despina Papamichail v Aliona Bolsova [224] | 6-1,6-2 | |
| ITF W60 Prague | 05/03 08:30 | 25 | [268] Maja Chwalinska v Despina Papamichail [172] | 7-6,6-1 | |
| ITF W60 Zagreb | 04/27 13:35 | 26 | [172] Despina Papamichail v Petra Marcinko [388] | 1-6,3-6 | |
| ITF W60 Zagreb | 04/26 07:50 | 25 | [172] Despina Papamichail v Jana Fett [236] | Retired | |
| WTA Istanbul | 04/18 16:30 | 19 | [96] Qiang Wang v Despina Papamichail [173] | 6-1,6-1 | |
| WTA Istanbul | 04/17 09:15 | 14 | [200] Ysaline Bonaventure v Despina Papamichail [172] | 4-6,6-7 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.