| Australian Open Women | 01/11 04:45 | 15 | [158] Despina Papamichail v Olga Danilovic [153] | 3-6,1-6 | |
| Australian Open Women | 01/10 02:05 | 14 | [111] Reka-Luca Jani v Despina Papamichail [158] | 1-6,0-6 | |
| United Cup Women | 01/07 08:50 | 28 | [158] Despina Papamichail v Lucia Bronzetti [54] | Cancelled | |
| United Cup Women | 01/04 04:30 | 19 | [158] Despina Papamichail v Donna Vekic [67] | 2-6,0-6 | |
| United Cup Women | 01/02 04:00 | - | [158] Despina Papamichail v Alison Van Uytvanck [72] | 5-7,6-2,3-6 | |
| United Cup Women | 12/29 04:00 | - | [158] Despina Papamichail v Isabella Shinikova [381] | 3-6,6-4,6-1 | |
| ITF W80 Valencia | 11/23 10:20 | 25 | [159] Despina P'michail v Sada Nahimana [265] | 4-6,3-6 | |
| ITF W80 Madrid | 11/16 10:25 | 25 | [155] Despina Papamichail v Marie Benoit [279] | 3-6,6-7 | |
| WTA Colina | 11/10 15:00 | 26 | [129] Victoria Jimenez Kasintseva v Despina Papamichail [156] | 6-1,6-2 | |
| WTA Colina | 11/08 16:25 | 25 | [156] Despina Papamichail v Darya Astakhova [221] | 6-3,6-3 | |
| ITF W60 Barranquilla | 11/02 17:40 | 25 | Despina Papamichail v Raveena Kingsley | 3-6,6-3,2-6 | |
| ITF W60 Hamburg | 10/20 14:25 | 26 | [404] Julia Middendorf v Despina Papamichail [143] | 7-6,3-6,6-4 | |
| ITF W60 Hamburg | 10/19 08:00 | 25 | [390] Veronika Erjavec v Despina Papamichail [143] | 6-3,2-6,3-6 | |
| ITF W60 Monastir | 10/15 11:55 | 28 | [136] Kristina Mladenovic v Despina Papamichail [152] | 6-2,6-4 | |
| ITF W60 Monastir | 10/14 09:00 | 27 | [280] Weronika Falkowska v Despina Papamichail [152] | 3-6,6-1,2-6 | |
| ITF W60 Monastir | 10/13 11:00 | 26 | [237] Isabella Shinikova v Despina Papamichail [152] | 6-3,3-6,6-7 | |
| ITF W60 Monastir | 10/12 12:15 | 25 | [121] Estelle Cascino v Despina Papamichail [152] | 1-6,3-6 | |
| WTA Monastir | 10/05 17:00 | 26 | [175] Despina Papamichail v Elise Mertens [42] | 7-5,1-6,2-6 | |
| WTA Monastir | 10/03 10:00 | 25 | [64] Lin Zhu v Despina Papamichail [175] | 6-1,6-7,0-6 | |
| WTA Monastir | 10/02 09:00 | 19 | [130] Kristina Mladenovic v Despina Papamichail [175] | 6-2,2-6,4-6 | |
| WTA Monastir | 10/01 11:50 | 14 | [432] Ines Ibbou v Despina Papamichail [175] | 3-6,2-6 | |
| WTA Tokyo | 09/21 02:00 | 26 | [213] Despina Papamichail v Garbine Muguruza [12] | 4-6,2-6 | |
| WTA Tokyo | 09/19 11:20 | 25 | [328] Xiaodi You v Despina Papamichail [213] | 4-6,2-6 | |
| WTA Tokyo | 09/18 02:00 | 19 | [197] Despina Papamichail v Himeno Sakatsume [357] | 6-2,6-4 | |
| WTA Tokyo | 09/17 02:30 | 14 | [197] Despina Papamichail v Erika Sema [426] | 6-4,4-6,6-4 | |
| WTA Chennai | 09/13 13:10 | 25 | [142] Oksana Selekhmeteva v Despina Papamichail [197] | 6-3,6-1 | |
| ITF W60 Prague | 08/31 10:25 | 25 | [296] Barbora Palicova v Despina Papamichail [188] | 6-4,7-5 | |
| US Open Women | 08/23 16:25 | 14 | [195] Mai Hontama v Despina Papamichail [187] | 6-2,6-2 | |
| WTA Vancouver | 08/15 20:10 | 25 | [187] Despina Papamichail v Catherine Harrison [251] | 1-6,3-6 | |
| WTA Iasi | 08/02 11:05 | 25 | [186] Despina Papamichail v Panna Udvardy [93] | 3-6,5-7 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.