| Billie Jean King Cup | 04/15 13:15 | 2 | [172] Despina Papamichail v Mandy Minella [251] | 1-6,0-6 | |
| Billie Jean King Cup | 04/14 14:10 | 2 | [172] Despina Papamichail v Maiar S A Abdelaziz [62] | 3-6,3-6 | |
| Billie Jean King Cup | 04/13 13:25 | 2 | [172] Despina Papamichail v Ulrikke Eikeri [239] | 2-6,7-5,6-4 | |
| WTA Bogota | 04/04 15:00 | 25 | [172] Despina Papamichail v Lucrezia Stefanini [159] | 3-6,4-6 | |
| ITF W25 Le Havre | 03/24 10:00 | 26 | [253] Irene Burillo Escorihuela v Despina Papamichail [171] | 7-5,3-6,7-6 | |
| ITF W25 Le Havre | 03/22 11:15 | 25 | Astrid Lew Yan Foon v Despina Papamichail | 0-6,0-6 | |
| ITF W25 Antalya | 03/16 07:00 | 25 | Nicole Khirin v Despina Papamichail | 7-6,6-1 | |
| WTA Lyon | 02/26 15:00 | 14 | [176] Despina Papamichail v Mariam Bolkvadze [161] | 6-3,4-6,1-6 | |
| WTA Guadalajara | 02/19 20:30 | 14 | Viktoria Kuzmova v Despina Papamichail | 6-4,6-3 | |
| ITF W25 Cancun | 02/09 18:00 | 25 | Despina Papamichail v Stacey Fung | 2-6,4-6 | |
| ITF W60 Rome GA | 02/03 15:50 | 26 | [175] Despina Papamichail v Francesca Di Lorenzo [203] | 1-6,3-6 | |
| ITF W60 Rome GA | 02/01 18:25 | 25 | [175] Despina Papamichail v Jodie Anna Burrage [209] | 6-7,7-6,6-0 | |
| ITF W60 Orlando | 01/27 16:25 | 25 | [181] Despina Papamichail v Qinwen Zheng [108] | 4-6,2-6 | |
| Australian Open Women | 01/10 23:00 | 14 | [119] Viktoriya Tomova v Despina Papamichail [183] | 6-2,4-6,6-1 | |
| WTA Adelaide | 01/04 06:20 | 25 | [182] Despina Papamichail v Marie Bouzkova [90] | 3-6,0-6 | |
| WTA Adelaide | 01/03 07:05 | 19 | [147] Stefanie Voegele v Despina Papamichail [182] | 4-6,6-7 | |
| WTA Adelaide | 01/02 07:50 | 14 | [182] Despina Papamichail v Francesca Jones [151] | 3-6,6-2,6-1 | |
| WTA Buenos Aires | 11/05 13:00 | 27 | [135] Anna Bondar v Despina Papamichail [199] | 6-4,7-5 | |
| WTA Buenos Aires | 11/04 13:00 | 26 | Solana Sierra v Despina Papamichail | 6-7,4-6 | |
| WTA Buenos Aires | 11/02 18:00 | 25 | [261] Maria Lourdes Carle v Despina Papamichail [199] | 6-3,2-6,2-6 | |
| ITF W25 Seville | 10/19 12:40 | 25 | Yvonne Cavalle-Reimers v Despina Papamichail | 6-2,6-4 | |
| ITF W25 Lagos | 10/16 10:35 | 28 | Despina Papamichail v Antonia Ruzic | 1-6,1-6 | |
| ITF W25 Lagos | 10/15 12:00 | 27 | [210] Despina Papamichail v Naiktha Bains [264] | 6-1,6-1 | |
| ITF W25 Lagos | 10/14 12:00 | 26 | [210] Despina Papamichail v Miriam B Bulgaru [404] | 3-6,6-3,7-6 | |
| ITF W25 Lagos | 10/13 12:55 | 25 | Despina Papamichail v Ines Murta | 6-3,6-4 | |
| ITF W25 Loule | 10/06 11:10 | 25 | [468] Angela Fita Boluda v Despina Papamichail [210] | 6-3,6-3 | |
| ITF W80 Valencia | 09/23 10:30 | 26 | [160] Francesca Jones v Despina Papamichail [215] | 7-6,6-1 | |
| ITF W80 Valencia | 09/22 11:30 | 25 | [200] Diane Parry v Despina Papamichail [215] | 3-6,3-6 | |
| ITF W80 Valencia | 09/16 08:25 | 26 | [222] Despina Papamichail v Panna Udvardy [161] | 7-6,1-6,4-6 | |
| ITF W80 Valencia | 09/15 12:30 | 25 | [131] Ysaline Bonaventure v Despina Papamichail [222] | 4-6,2-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.