| ITF W25 Platja D’Aro | 05/19 13:55 | 25 | [296] En Shuo Liang v Despina Papamichail [273] | 5-7,2-6 | |
| ITF W100 Bonita Springs | 05/12 21:45 | 25 | [133] Irina Maria Bara v Despina Papamichail [270] | 6-3,6-1 | |
| ITF W100 Bonita Springs | 05/11 14:00 | 54 | [211] Aleksandra Krunic v Despina Papamichail [270] | 6-3,5-7,12-14 | |
| ITF W100 Bonita Springs | 05/10 19:00 | 54 | [289] Anna Danilina v Despina Papamichail [270] | 5-7,3-6 | |
| ITF W25 Naples | 05/06 13:00 | 26 | [270] Despina Papamichail v Irina Fetecau [307] | 1-6,2-6 | |
| ITF W25 Naples | 05/05 17:30 | 25 | [270] Despina Papamichail v Emiliana Arango [479] | 7-5,2-6,7-5 | |
| ITF W60 Oeiras | 04/17 10:40 | 27 | [195] Georgina Garcia-Perez v Despina Papamichail [276] | 6-4,6-1 | |
| ITF W60 Oeiras | 04/16 09:25 | 29 | [276] Despina Papamichail v Greet Minnen [118] | 6-4,6-0 | |
| ITF W60 Oeiras | 04/14 14:45 | 25 | [213] Martina Di Giuseppe v Despina Papamichail [276] | 1-6,4-6 | |
| ITF W60 Oeiras | 04/13 15:30 | 24 | [448] Sina Herrmann v Despina Papamichail [276] | 2-6,6-1,6-7 | |
| ITF W25 Cordoba | 04/08 13:00 | 26 | Despina Papamichail v Panna Udvardy | 3-6,6-2,2-6 | |
| ITF W25 Cordoba | 04/07 15:10 | 25 | [272] Andrea Lazaro Garcia v Despina Papamichail [275] | 4-6,5-7 | |
| ITF W25 Villa Maria | 04/01 17:35 | 26 | [277] Susan Bandecchi v Despina Papamichail [278] | 6-0,7-6 | |
| ITF W25 Villa Maria | 03/30 17:55 | 25 | [278] Despina Papamichail v Diana Marcinkevica [281] | 1-6,7-6,6-3 | |
| ITF W25 Buenos Aires | 03/23 15:55 | 25 | [278] Despina Papamichail v Yuki Naito [189] | 6-1,1-6,4-6 | |
| ITF W25 Newport Beach | 03/05 17:30 | 26 | [356] Beatriz Haddad Maia v Despina Papamichail [279] | 6-0,7-5 | |
| ITF W25 Newport Beach | 03/03 22:00 | 25 | [267] Katherine Sebov v Despina Papamichail [279] | 4-6,7-6,3-6 | |
| ITF W25 Boca Raton | 02/25 17:20 | 26 | [277] Despina Papamichail v Gabriela Talaba [213] | 6-4,3-6,3-6 | |
| ITF W25 Boca Raton | 02/24 20:00 | 25 | [303] Ana Sofia Sanchez v Despina Papamichail [277] | 7-5,5-7,3-6 | |
| ITF W25 Boca Raton | 02/24 19:30 | 25 | Anhelina Kalinina v Despina Papamichail | Cancelled | |
| ITF W25 Boca Raton | 02/23 18:55 | 54 | [277] Despina Papamichail v Ana Sofia Sanchez [303] | 6-3,6-2 | |
| ITF W25 Boca Raton | 02/22 15:00 | 54 | Despina Papamichail v Barbara Gatica | 7-6,6-3 | |
| ITF W25 Orlando | 02/15 15:30 | 54 | Despina Papamichail v Lucrezia Stefanini | 2-6,3-6 | |
| ITF W60 Rome GA | 01/28 20:10 | 26 | [331] Irene Burillo Escorihuela v Despina Papamichail [277] | 6-2,6-1 | |
| ITF W60 Rome GA | 01/27 16:50 | 25 | [277] Despina Papamichail v Francesca Di Lorenzo [143] | 6-3,6-1 | |
| ITF W25 Hamburg | 01/12 11:30 | 25 | [371] Marina B Ribera v Despina Papamichail [278] | 6-2,6-7,6-1 | |
| WTA Abu Dhabi | 01/07 13:35 | 24 | [278] Despina Papamichail v Karolina Pliskova [6] | 2-6,6-7 | |
| WTA Abu Dhabi | 01/06 06:00 | 19 | [278] Despina Papamichail v Zhaoxuan Yang [55] | 2-6,2-6 | |
| WTA Abu Dhabi | 01/05 08:05 | 64 | [278] Despina Papamichail v Federica Di Sarra [320] | 2-6,7-5,6-1 | |
| ITF W25 LPD Gran Canaria | 11/18 10:00 | 25 | [287] Amandine Hesse v Despina Papamichail [276] | 3-6,6-4,6-3 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.