| ITF W60 Caserta | 06/07 11:00 | 25 | [158] Despina Papamichail v Vivian Wolff [493] | 2-6,3-6 | |
| ITF W60 Brescia | 06/01 09:00 | 26 | [158] Despina Papamichail v Yuliya Hatouka [263] | 4-6,2-6 | |
| ITF W60 Brescia | 05/31 07:30 | 25 | Despina Papamichail v Claudia Hoste Ferrer | 6-2,6-3 | |
| French Open Women | 05/23 08:00 | 14 | [157] Despina Papamichail v Moyuka Uchijima [145] | 2-6,2-6 | |
| ITF W100 Madrid | 05/16 08:50 | 25 | [183] Mai Hontama v Despina Papamichail [157] | 6-4,6-1 | |
| WTA Rome | 05/08 09:35 | 14 | [107] Arantxa Rus v Despina Papamichail [157] | 6-2,6-1 | |
| WTA Saint-Malo | 05/02 09:00 | 25 | Elina Svitolina v Despina Papamichail | 7-5,6-1 | |
| WTA Madrid | 04/24 10:35 | 14 | [76] Nuria Parrizas-Diaz v Despina Papamichail [152] | 7-6,6-2 | |
| Billie Jean King Cup | 04/15 11:30 | 2 | [69] Anett Kontaveit v Despina Papamichail [151] | 2-6,4-6 | |
| Billie Jean King Cup | 04/14 11:40 | 2 | [151] Despina Papamichail v Francisca Jorge [314] | 5-7,6-7 | |
| Billie Jean King Cup | 04/13 10:50 | - | [151] Despina Papamichail v Nefisa Berberovic [319] | 4-6,4-6 | |
| Billie Jean King Cup | 04/12 11:50 | 2 | Despina Papamichail v Francesca Curmi | 6-4,6-7,4-6 | |
| Billie Jean King Cup | 04/11 11:15 | 2 | [151] Despina Papamichail v Lina Glushko [271] | 6-1,6-1 | |
| WTA Bogota | 04/04 17:40 | 25 | [152] Despina Papamichail v Nuria Brancaccio [206] | 2-6,2-6 | |
| WTA San Luis Potosi | 03/29 00:25 | 25 | [151] Despina Papamichail v Aliona Bolsova [152] | 1-6,6-3,4-6 | |
| WTA Monterrey | 02/27 19:50 | 25 | [150] Despina Papamichail v Ysaline Bonaventure [96] | 6-7,6-4,1-6 | |
| WTA Monterrey | 02/26 18:30 | 19 | [126] Marina B Ribera v Despina Papamichail [151] | 4-6,4-6 | |
| WTA Monterrey | 02/25 22:30 | 14 | Lya I F Olivares v Despina Papamichail | 1-6,1-6 | |
| WTA Merida | 02/18 21:40 | 14 | [108] Leolia Jeanjean v Despina Papamichail [155] | 7-5,1-6,6-3 | |
| ITF W60 Irapuato | 02/16 20:30 | 26 | [67] Xinyu Wang v Despina Papamichail [155] | 4-6,6-4,7-6 | |
| ITF W60 Irapuato | 02/15 22:10 | 25 | [362] Ana Sofia Sanchez v Despina Papamichail [155] | 3-6,4-6 | |
| ITF W40 Mexico City | 02/09 16:30 | 27 | [368] Jana Kolodynska v Despina Papamichail [154] | 6-3,7-6 | |
| ITF W40 Mexico City | 02/08 16:30 | 26 | [280] Sofia Sewing v Despina Papamichail [154] | 2-6,5-7 | |
| ITF W40 Mexico City | 02/07 15:30 | 25 | [364] Sofia Costoulas v Despina Papamichail [154] | 6-7,2-6 | |
| ITF W40 Mexico City | 02/03 17:00 | 28 | [346] Berfu Cengiz v Despina Papamichail [151] | 6-7,6-4,6-3 | |
| ITF W40 Mexico City | 02/02 16:30 | 27 | [337] Emina Bektas v Despina Papamichail [151] | 6-2,4-6,2-6 | |
| ITF W40 Mexico City | 02/01 17:15 | 26 | [373] Jana Kolodynska v Despina Papamichail [151] | 6-2,3-6,6-7 | |
| ITF W40 Mexico City | 01/31 20:20 | 25 | Mao Mushika v Despina Papamichail | 2-6,6-4,2-6 | |
| ITF W60 Sunderland | 01/26 10:00 | 26 | [157] Despina Papamichail v Magali Kempen [211] | 4-6,0-6 | |
| ITF W60 Sunderland | 01/24 10:00 | 25 | [157] Despina Papamichail v Lena Papadakis [255] | 6-4,7-6 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993 in Preveza) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 109, achieved on 18 September 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 36 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 25–28 (as of January 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event, by defeating Gabriela Cé. It was her first title above $25k level.
She made her main-draw WTA Tour singles debut at the WTA 500 2021 Abu Dhabi Open.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
She qualified for the 2023 Toray Pan Pacific Open and defeated lucky loser Sakura Hosogi.